Study of Attenuation Correction Using a Cardiac Dynamic Phantom: Synchronized Time-Phase-Gated Attenuation Correction Method

Narihiro Hara; Masahisa Onoguchi; Hiroyuki Kawaguchi; Noriko Matsushima; Osamu Houjou; Masakazu Murai; Kohei Nakano; Wakana Makino

doi:10.2967/jnmt.123.266785

Study of Attenuation Correction Using a Cardiac Dynamic Phantom: Synchronized Time-Phase-Gated Attenuation Correction Method

J Nucl Med Technol. 2024 Apr 16:jnmt.123.266785. doi: 10.2967/jnmt.123.266785. Online ahead of print.

Authors

Narihiro Hara¹, Masahisa Onoguchi², Hiroyuki Kawaguchi³, Noriko Matsushima³, Osamu Houjou³, Masakazu Murai³, Kohei Nakano³, Wakana Makino⁴

Affiliations

¹ Radiological Technology, Sumitomo Hospital, Osaka, Japan; hara-narihiro@sumitomo-hp.or.jp.
² Graduate School of Medical Sciences, Kanazawa University, Kanazawa, Japan; and.
³ Radiological Technology, Sumitomo Hospital, Osaka, Japan.
⁴ Department of Cardiology, Sumitomo Hospital, Osaka, Japan.

PMID: 38627013
DOI: 10.2967/jnmt.123.266785

Abstract

In cardiac nuclear medicine examinations, absorption in the body is the main factor in the degradation of the image quality. The Chang and external source methods were used to correct for absorption in the body. However, fundamental studies on attenuation correction for electrocardiogram (ECG)-synchronized CT imaging have not been performed. Therefore, we developed and improved an ECG-synchronized cardiac dynamic phantom and investigated the synchronized time-phase-gated attenuation correction (STPGAC) method using ECG-synchronized SPECT and CT images of the same time phase. Methods: As a basic study, SPECT was performed using synchronized time-phase-gated (STPG) SPECT and non-phase-gated (NPG) SPECT. The attenuation-corrected images were, first, CT images with the same time phase as the ECG waveform of the gated SPECT acquisition (with CT images with the ECG waveform of the CT acquisition as the reference); second, CT images with asynchronous ECG; third, CT images of the 75% region; and fourth, CT images of the 40% region. Results: In the analysis of cardiac function in the phantom experiment, left ventricle ejection fraction (heart rate, 11.5%-13.4%; myocardial wall, 49.8%-55.7%) in the CT images was compared with that in the STPGAC method (heart rate, 11.5%-13.3%; myocardial wall, 49.6%-55.5%), which was closer in value to that of the STPGAC method. In the phantom polar map segment analyses, none of the images showed variability (F _(10,10) < 0.5, P = 0.05). All images were correlated (r = 0.824-1.00). Conclusion: In this study, we investigated the STPGAC method using a SPECT/CT system. The STPGAC method showed similar values of cardiac function analysis to the CT images, suggesting that the STPGAC method accurately reconstructed the distribution of blood flow in the myocardial region. However, the target area for attenuation correction of the heart region was smaller than that of the whole body, and changing the gated SPECT conditions and attenuation-corrected images did not affect myocardial blood flow analysis.

Keywords: SPECT/CT system; electrocardiography-synchronized CT imaging; myocardial blood flow; synchronized time-phase–gated SPECT; synchronized time-phase–gated attenuation correction electrocardiogram.