Talaromides A-C, Bioactive Cyclic Heptapeptides from Talaromyces siglerae Isolated from a Marine Sponge

Youbin Cho; Kyu-Hyung Park; Eunhee Kim; Seungjin Kim; Weihong Wang; Hyukjae Choi; Heonjoong Kang

doi:10.1021/acs.jnatprod.3c01227

Talaromides A-C, Bioactive Cyclic Heptapeptides from Talaromyces siglerae Isolated from a Marine Sponge

J Nat Prod. 2024 Apr 26;87(4):1230-1234. doi: 10.1021/acs.jnatprod.3c01227. Epub 2024 Apr 16.

Authors

Youbin Cho¹, Kyu-Hyung Park¹, Eunhee Kim¹, Seungjin Kim¹, Weihong Wang^{1

2}, Hyukjae Choi³, Heonjoong Kang^{1

2

4}

Affiliations

¹ Laboratory of Marine Drugs, School of Earth and Environmental Sciences, Seoul National University, NS-80, Seoul 08826, Korea.
² Research Institute of Oceanography, Seoul National University, NS-80, Seoul 08826, Korea.
³ College of Pharmacy, Yeungnam University, Gyeongsan 38541, Korea.
⁴ Interdisciplinary Graduate Program in Genetic Engineering, Seoul National University, NS-80, Seoul 08826, Korea.

PMID: 38626456
DOI: 10.1021/acs.jnatprod.3c01227

Abstract

Three new cyclic heptapeptides, talaromides A-C (1-3), were isolated from cultures produced by the fungus Talaromyces siglerae (Ascomycota), isolated from an unidentified sponge. The structures, featuring an unusual proline-anthranilic moiety, were elucidated by analysis of spectroscopic data and chemical transformations, including the advanced Marfey's method and GITC derivatization. Talaromides A and B inhibited migration activity against PANC-1 human pancreatic cancer cells without significant cytotoxicity.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Antineoplastic Agents / chemistry
Antineoplastic Agents / isolation & purification
Antineoplastic Agents / pharmacology
Drug Screening Assays, Antitumor
Humans
Marine Biology
Molecular Structure
Peptides, Cyclic* / chemistry
Peptides, Cyclic* / isolation & purification
Peptides, Cyclic* / pharmacology
Porifera* / microbiology
Talaromyces* / chemistry

Substances

Peptides, Cyclic
Antineoplastic Agents