Gold-Catalyzed Reactions of Enynals with Alkenes for Synthesis Binaphthyl Derivatives

Jun-Jie Hao; Juan Wu; Tao Jiang; Hejiang Luo; Rong-Tao Li

doi:10.1021/acs.joc.4c00036

Gold-Catalyzed Reactions of Enynals with Alkenes for Synthesis Binaphthyl Derivatives

J Org Chem. 2024 May 3;89(9):6074-6084. doi: 10.1021/acs.joc.4c00036. Epub 2024 Apr 16.

Authors

Jun-Jie Hao¹, Juan Wu¹, Tao Jiang¹, Hejiang Luo¹, Rong-Tao Li¹

Affiliation

¹ Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, 650500, P. R. China.

PMID: 38626391
DOI: 10.1021/acs.joc.4c00036

Abstract

A PPh₃Au[B(C₆F₅)₄]-catalyzed reaction of enynals and alkenes for the construction of binaphthyl derivatives was described. This transformation was achieved through o-Quinodimethane (o-QDM) intermediate's extended conjugated addition process. The reaction has the advantages of wide substrate scopes, mild reaction conditions, high efficiency, and good scalability.