Effects of cycloplegia on crystalline lens morphology and location in acute acquired concomitant esotropia

Weibin Chen; Jiawen Liu; Wei Dai; Jie Hao; Jiayu Chen; Jing Fu

doi:10.1007/s00417-024-06484-z

Effects of cycloplegia on crystalline lens morphology and location in acute acquired concomitant esotropia

Graefes Arch Clin Exp Ophthalmol. 2024 Apr 16. doi: 10.1007/s00417-024-06484-z. Online ahead of print.

Authors

Weibin Chen¹, Jiawen Liu², Wei Dai¹, Jie Hao¹, Jiayu Chen¹, Jing Fu³

Affiliations

¹ Beijing Key Laboratory of Ophthalmology & Visual Sciences, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing, China.
² Wilmer Eye Institute, School of Medicine, Johns Hopkins University, Baltimore, MD, USA.
³ Beijing Key Laboratory of Ophthalmology & Visual Sciences, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing, China. fu_jing@126.com.

PMID: 38625449
DOI: 10.1007/s00417-024-06484-z

Abstract

Purpose: The study aims to compare morphology and location of crystalline lens between acute acquired concomitant esotropia (AACE) patients and control subjects, both before and after cycloplegia.

Methods: This is a prospective and observational clinical study. Morphological and locational parameters of the crystalline lens in 53 AACE patients and 32 control subjects were assessed before and after cycloplegia using CASIA2 system, which represents the latest swept-source anterior segment optical coherence tomography. Cycloplegic refraction was recorded by administering 1% atropine in patients younger than 12 years and 1% cyclopentolate in those > 12 years old. Morphological parameters included anterior radius of curvature (ARC), posterior radius of curvature (PRC), lens thickness (LTH), and equivalent diameter of lens (LED). Locational parameters comprised lens decentration (LD) and lens tilt (LT). Comparison of these parameters before and after cycloplegia were conducted between AACE and controls. Additionally, the study analyzed and compared the changes in these parameter post-cycloplegia.

Results: Our findings suggest no significant difference in morphological parameters including ARC, PRC, LTH and LED between AACE patients and controls before or after cycloplegia. However, 2D-modeling data in the 0° meridian revealed that variation post-cycloplegia of LD (lens shift) in right eyes was different in AACE patients, measuring - 0.03(0.08) [median(interquartile range)] which was significantly distinct from the control group, exhibiting a measurement of 0.01(0.06) (z = - 2.373, p = 0.018). In left eyes, a similar trend was observed with lens shift in the 0° meridian being 0.02(0.06) in AACE, significantly differing from control group's measurement of - 0.02(0.08) (z = - 2.809, p = 0.005). Further, correlation analysis revealed that larger temporal shift of lens was associated with greater changes in ARC (r = 0.294, p = 0.006) and LTH (r = - 0.230, p = 0.031).

Conclusions: The morphological features of the crystalline lens were similar in AACE patients and controls; however, the change of lens location by cycloplegia was observed only in AACE patients, suggesting an association with excessive accommodation.

Keywords: Acute acquired concomitant esotropia; CASIA2; Cycloplegia; Lens location; Lens morphology.

Abstract

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