Acute toxicity of praziquantel to fish Danio rerio and planktonic crustacean Daphnia magna

Eliska Zuskova; Veronika Piackova; Olga Valentova; Klara Zalohova; Josef Velisek

doi:10.17221/7/2022-VETMED

Acute toxicity of praziquantel to fish Danio rerio and planktonic crustacean Daphnia magna

Vet Med (Praha). 2022 Oct 24;67(11):579-584. doi: 10.17221/7/2022-VETMED. eCollection 2022 Oct.

Authors

Eliska Zuskova¹, Veronika Piackova¹, Olga Valentova¹, Klara Zalohova¹, Josef Velisek¹

Affiliation

¹ South Bohemian Research Center of Aquaculture and Biodiversity of Hydrocenoses, Faculty of Fisheries and Protection of Waters, University of South Bohemia in Ceske Budejovice, Ceske Budejovice, Czech Republic.

Abstract

This study evaluated the toxicity of the pyrazino isoquinoline anthelmintic praziquantel (PZQ) to the Danio rerio zebrafish and Daphnia magna water flea. The estimated 24 h and 96 h LC50 of PZQ to the zebrafish was 39.9 mg/l and 30.4 mg/l, respectively. The highest 24 h and 96 h non-lethal concentration (LC0) was 21.7 mg/l and 21.2 mg/l, respectively. The mobility inhibition test of the juvenile Daphnia magna revealed a 48 h EC50 of 42.7 mg/l.

Keywords: 96 h LC50; antiparasitic; bath treatment; water flea; zebrafish.

Grants and funding

Supported by the Ministry of Agriculture of the Czech Republic (Project No. QK21010113) and by the Ministry of Education, Youth and Sports of the Czech Republic, Project: Sustainable Production of Healthy Fish in Various Aquaculture Systems, PROFISH (No. CZ.02.1.01/0.0/0.0/16_019/0000869).