Potential implication of serum lipid levels as predictive indicators for monitoring oral lichen planus

Xuan Xiao; Zhifeng Song; Shangfeng Liu

doi:10.1016/j.jds.2023.12.026

Potential implication of serum lipid levels as predictive indicators for monitoring oral lichen planus

J Dent Sci. 2024 Apr;19(2):1307-1311. doi: 10.1016/j.jds.2023.12.026. Epub 2024 Jan 24.

Authors

Xuan Xiao^{1

2}, Zhifeng Song^{1

2}, Shangfeng Liu²

Affiliations

¹ Department of Oral Mucosa, Shanghai Stomatological Hospital & School of Stomatology, Fudan University, Shanghai, China.
² Shanghai Key Laboratory of Craniomaxillofacial Development and Diseases, Fudan University, Shanghai, China.

Abstract

Compelling evidence indicates that dyslipidemia is positively associated with oral lichen planus (OLP). The types and magnitude of lipid metabolism disturbance in peripheral blood of OLP patients have been investigated in different studies. Yet, consensus on how these different lipid components varied in levels for the development of OLP lesions has not been reached so far. Herein, a total of 8 eligible studies were recognized, which enrolled 533 cases of OLP and 499 healthy controls. The analysis showed that the average total triglyceride (TG), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C) levels were considerably higher, and high-density lipoprotein cholesterol (HDL-C) levels were significantly lower in OLP patients compared to healthy controls. Collectively, the lipid profile panel maybe serve as the potential predictive indicator for screening OLP.

Keywords: Dyslipidemia; Oral lichen planus; Serum; Total cholesterol; Triglycerides.