High Monocyte-to-Lymphocyte Ratio is Associated with Obstructive Sleep Apnea Hypopnea Syndrome

Wenyu Bao; Junkang Gao; Siyu Fang; Shiwei Zhang; Yufeng Wan

doi:10.2147/JIR.S455559

High Monocyte-to-Lymphocyte Ratio is Associated with Obstructive Sleep Apnea Hypopnea Syndrome

J Inflamm Res. 2024 Apr 8:17:2137-2145. doi: 10.2147/JIR.S455559. eCollection 2024.

Authors

Wenyu Bao^#¹, Junkang Gao^#¹, Siyu Fang¹, Shiwei Zhang¹, Yufeng Wan¹

Affiliation

¹ Department of Otolaryngology, Head and Neck Surgery, Chaohu Hospital Affiliated to Anhui Medical University, Hefei, 238000, People's Republic of China.

^# Contributed equally.

Abstract

Objective: This study aims to explore the correlation between serum monocyte-to-lymphocyte ratio (MLR) and other inflammatory parameters with the occurrence of obstructive sleep apnea-hypopnea syndrome (OSAHS) in patients.

Methods: This study included 310 patients who underwent polysomnography monitoring at our hospital between January 2021 and January 2023. Routine blood inflammatory parameters and polysomnography (PSG) results were also evaluated. The differences in inflammatory markers between the OSAHS and normal groups were compared, and OSAHS independent related factors were screened.

Results: The MLR of OSAHS group was significantly higher than that of control group, and the difference was statistically significant. Multivariate logistic regression analysis suggested that MLR is an independent risk factor for OSAHS.

Conclusion: High MLR was correlated with OSAHS. The diagnostic value of MLR was better than that of the other inflammatory parameters.

Keywords: inflammation; monocyte to lymphocyte ratio; obstructive sleep apnea hypopnea syndrome; polysomnography.

Grants and funding

This study was supported by the Chaohu Hospital, affiliated with the Anhui Medical University Young and Middle-aged Personnel Training Fund (No. Z202002).