Metabolic regulation of the Th17/Treg balance in inflammatory bowel disease

Shunfen Zhang; Ruqing Zhong; Shanlong Tang; Liang Chen; Hongfu Zhang

doi:10.1016/j.phrs.2024.107184

Metabolic regulation of the Th17/Treg balance in inflammatory bowel disease

Pharmacol Res. 2024 May:203:107184. doi: 10.1016/j.phrs.2024.107184. Epub 2024 Apr 12.

Authors

Shunfen Zhang¹, Ruqing Zhong², Shanlong Tang², Liang Chen³, Hongfu Zhang⁴

Affiliations

¹ State Key Laboratory of Animal Nutrition and Feeding, Institute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing 100193, China; College of Animal Science and Technology, China Agricultural University, Beijing 100193, China.
² State Key Laboratory of Animal Nutrition and Feeding, Institute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing 100193, China.
³ State Key Laboratory of Animal Nutrition and Feeding, Institute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing 100193, China. Electronic address: chenliang01@caas.cn.
⁴ State Key Laboratory of Animal Nutrition and Feeding, Institute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing 100193, China. Electronic address: zhanghongfu@caas.cn.

PMID: 38615874
DOI: 10.1016/j.phrs.2024.107184

Abstract

Inflammatory bowel disease (IBD) is a long-lasting and inflammatory autoimmune condition affecting the gastrointestinal tract, impacting millions of individuals globally. The balance between T helper 17 (Th17) cells and regulatory T cells (Tregs) is pivotal in the pathogenesis and progression of IBD. This review summarizes the pivotal role of Th17/Treg balance in maintaining intestinal homeostasis, elucidating how its dysregulation contributes to the development and exacerbation of IBD. It comprehensively synthesizes the current understanding of how dietary factors regulate the metabolic pathways influencing Th17 and Treg cell differentiation and function. Additionally, this review presents evidence from the literature on the potential of dietary regimens to regulate the Th17/Treg balance as a strategy for the management of IBD. By exploring the intersection between diet, metabolic regulation, and Th17/Treg balance, the review reveals innovative therapeutic approaches for IBD treatment, offering a promising perspective for future research and clinical practice.

Keywords: Caloric restriction; Calorie level; IBD; Th17/Treg balance; Time-limited eating.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Animals
Diet
Humans
Inflammatory Bowel Diseases* / immunology
Inflammatory Bowel Diseases* / metabolism
T-Lymphocytes, Regulatory* / immunology
Th17 Cells* / immunology