Sinonasal inverted papilloma and predictors of health-related quality of life after endonasal endoscopic surgery: A prospective cohort study

Marc C den Heijer; Gonneke E Joustra; Karin M Vermeulen; Astrid G W Korsten-Meijer; Robert A Feijen

doi:10.1111/coa.14158

Sinonasal inverted papilloma and predictors of health-related quality of life after endonasal endoscopic surgery: A prospective cohort study

Clin Otolaryngol. 2024 Apr 13. doi: 10.1111/coa.14158. Online ahead of print.

Authors

Marc C den Heijer^{1

2}, Gonneke E Joustra^{1

2}, Karin M Vermeulen³, Astrid G W Korsten-Meijer¹, Robert A Feijen¹

Affiliations

¹ Department of Otorhinolaryngology - Head and Neck Surgery, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
² Graduate School of Medical Sciences, University of Groningen, Groningen, The Netherlands.
³ Department of Epidemiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.

PMID: 38613400
DOI: 10.1111/coa.14158

Abstract

Objectives: Existing knowledge on health-related quality of life (HRQoL) after surgical removal of sinonasal inverted papilloma (IP) is limited. Moreover, predictors for a better or worse post-operative HRQoL outcome are not known. Our aim was to assess HRQoL in all three health domains (physical, psychological, and social), track its post-operative trajectory, investigate if pre-operative observations could predict distinct post-operative HRQoL outcomes, and evaluate whether physicians' interventions could contribute to improved post-operative HRQoL.

Design: Prospective cohort study.

Setting: Tertiary referral hospital.

Participants: Seventy-four patients who underwent surgery for an IP were included. They were asked to fill in the Endonasal Endoscopic Sinus and Skull-Base Surgery Questionnaire (EES-Q) pre-operatively, and then 2 weeks, 3 months, and 1 year post-operatively.

Main outcome measures: Linear mixed models analyses were performed to evaluate the overall post-operative HRQoL and the separate health domains, as well as the impact of specific variables (sex, age, American Society of Anaesthesiologists [ASA] classification, smoker, Krouse staging, pre-operative EES-Q score, type of surgery, and post-operative antibiotics) on HRQoL improvement.

Results: The total EES-Q score (p < .001) as well as the physical (p < .001), psychological (p = .049), and the social (p = .002) domains significantly improved post-operatively. ASA classification (p = .049), pre-operative EES-Q score (p < .001) and post-operative antibiotics (p = .036) were significant variables.

Conclusions: Overall HRQoL, as well as each of the three health domains, improved significantly. A higher ASA score, a higher pre-operative EES-Q score, and the administration of post-operative antibiotics were significant predictors for better HRQoL recovery post-operatively. Further research is necessary to confirm these results.

Keywords: EES‐Q; health‐related quality of life; patient‐reported outcome measure; prospective cohort study; sinonasal inverted papilloma.