Medicinal and chemosensing applications of chitosan based material: A review

Khairia Mohammed Al-Ahmary; Saedah R Al-Mhyawi; Sikandar Khan; Kamelah S Alrashdi; Alaa Shafie; Ahmad O Babalghith; Amal Adnan Ashour; Tasneem H Alshareef; Ehssan Moglad

doi:10.1016/j.ijbiomac.2024.131493

Medicinal and chemosensing applications of chitosan based material: A review

Int J Biol Macromol. 2024 Apr 10;268(Pt 1):131493. doi: 10.1016/j.ijbiomac.2024.131493. Online ahead of print.

Authors

Khairia Mohammed Al-Ahmary¹, Saedah R Al-Mhyawi¹, Sikandar Khan², Kamelah S Alrashdi³, Alaa Shafie⁴, Ahmad O Babalghith⁵, Amal Adnan Ashour⁶, Tasneem H Alshareef⁷, Ehssan Moglad⁸

Affiliations

¹ Department of Chemistry, College of Science, University of Jeddah, Jeddah, Saudi Arabia.
² Department of Chemistry, University of Malakand, Khyber Pakhtunkhwa, Pakistan.
³ Department of Chemistry, Al-Qunfudah University College, Umm Al-Qura University, Al-Qunfudah 1109, Saudi Arabia.
⁴ Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, Taif University, P.O. Box 11099, Taif 21944, Saudi Arabia.
⁵ Medical Genetics Department, College of Medicine, Umm Al-Qura University, Makkah, Saudi Arabia.
⁶ Department of Oral & Maxillofacial Surgery and Diagnostic Sciences, Faculty of Dentistry, Taif University, P.O. Box 11099, Taif 21944, Saudi Arabia.
⁷ Department of Chemistry, College of Science and Arts, Najran University, Najran 11001, Saudi Arabia.
⁸ Department of Pharmaceutics, College of Pharmacy, Prince Sattam bin Abdulaziz University, P.O. Box 173, Alkharj, Saudi Arabia.

PMID: 38608983
DOI: 10.1016/j.ijbiomac.2024.131493

Abstract

Chitosan (CTS), has emerged as a highly intriguing biopolymer with widespread applications, drawing significant attention in various fields ranging from medicinal to chemosensing. Key characteristics of chitosan include solubility, biocompatibility, biodegradability and reactivity, making it versatile in numerous sectors. Several derivatives have been documented for their diverse therapeutic properties, such as antibacterial, antifungal, anti-diabetic, anti-inflammatory, anticancer and antioxidant activities. Furthermore, these compounds serve as highly sensitive and selective chemosensor for the detection of various analytes such as heavy metal ions, anions and various other species in agricultural, environmental and biological matrixes. CTS derivatives interacting with these species and give analytical signals. In this review, we embark on an exploration of the latest advancements in CTS-based materials, emphasizing their noteworthy contributions to medicinal chemistry spanning the years from 2021 to 2023. The intrinsic biological and physiological properties of CTS make it an ideal platform for designing materials that interact seamlessly with biological systems. The review also explores the utilization of chitosan-based materials for the development of colorimetric and fluorimetric chemosensors capable of detecting metal ions, anions and various other species, contributing to advancements in environmental monitoring, healthcare diagnostics, and industrial processes.

Keywords: Antibacterial; Anticancer; Biocompatibility; Biomolecules; Chemosensor.

Publication types

Review