The impact of baseline dietary fatty acid intake on the association between lipoprotein(a) and mortality in two US cohorts

Nimai Patel; Chaitanya Chennareddy; Eric J Brandt

doi:10.1177/20480040241247394

The impact of baseline dietary fatty acid intake on the association between lipoprotein(a) and mortality in two US cohorts

JRSM Cardiovasc Dis. 2024 Apr 11:13:20480040241247394. doi: 10.1177/20480040241247394. eCollection 2024 Jan-Dec.

Authors

Nimai Patel¹, Chaitanya Chennareddy², Eric J Brandt^{3

4}

Affiliations

¹ Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA.
² University of Michigan, Ann Arbor, MI, USA.
³ Division of Cardiology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA.
⁴ Institute for Healthcare Policy and Innovation, University of Michigan, Ann Arbor, MI, USA.

Abstract

Background: Lipoprotein(a) (Lp(a)) is an established casual risk factor for atherosclerotic cardiovascular disease. It remains unknown whether dietary fat modifies the association of Lp(a) with cardiovascular death.

Aim: To understand if dietary fat modifies the association between Lp(a) and cardiovascular death.

Methods: We utilized the Atherosclerotic Risk in Communities (ARIC) study and National Health and Nutrition Examination Survey (NHANES) III cohorts and used multivariate cox proportional hazard modeling to test the association between Lp(a), dietary fats, and cardiovascular death.

Results: The sample (n = 22,805) had average age 51.3 years and was mostly female (55.4%). Lp(a) ≥ 30 mg/dL was associated with CV death in both ARIC (1.36, p = 0.001) and NHANES (1.31, p = 0.03). In multivariate analysis, no categorical or individual fatty acids modified the association between Lp(a) and CV death.

Conclusion: There was no evidence that baseline dietary fat intake modified the association between Lp(a) and CV death.

Keywords: ASCVD; Lipoprotein(a); cardiovascular mortality; dietary fat.