A minireview on covalent organic frameworks as stationary phases in chromatography

Raquel Gavara; Sergio Royuela; Félix Zamora

doi:10.3389/fchem.2024.1384025

A minireview on covalent organic frameworks as stationary phases in chromatography

Front Chem. 2024 Mar 28:12:1384025. doi: 10.3389/fchem.2024.1384025. eCollection 2024.

Authors

Raquel Gavara^{1

2}, Sergio Royuela¹, Félix Zamora^{1

3}

Affiliations

¹ Departamento de Química Inorgánica, Facultad de Ciencias, Universidad Autónoma de Madrid, Madrid, Spain.
² Institute for Advanced Research in Chemical Sciences (IAdChem), Universidad Autónoma de Madrid, Madrid, Spain.
³ Condensed Matter Physics Center (IFIMAC), Universidad Autónoma de Madrid, Madrid, Spain.

Abstract

Advances in the design of novel porous materials open new avenues for the development of chromatographic solid stationary phases. Covalent organic frameworks (COFs) are promising candidates in this context due to their remarkable structural versatility and exceptional chemical and textural properties. In this minireview, we summarize the main strategies followed in recent years to apply these materials as stationary phases for chromatographic separations. We also comment on the perspectives of this new research field and potential directions to expand the applicability and implementation of COF stationary phases in analytical systems.

Keywords: COF; COF composites; COF processability; COF stationary phase; chromatography.

Publication types

Review

Grants and funding

The author(s) declare that financial support was received for the research, authorship, and/or publication of this article. We thank the financial support to the Spanish MICINN (PID 2022-138908NB-C31, PDC 2022-133498-I00 and TED 2021-129886B-C42) and through the “María de Maeztu” Programme for Units of Excellence in R&D (CEX 2018-000805-M). This work was also supported by the Comunidad de Madrid (MAD2D-CM) and MICINN (Planes complementarios, Materiales Avanzados). FZ also acknowledges support from the European Innovation Council under grant Agreement 101047081 (EVA).