brainlife.io: a decentralized and open-source cloud platform to support neuroscience research

Soichi Hayashi; Bradley A Caron; Anibal Sólon Heinsfeld; Sophia Vinci-Booher; Brent McPherson; Daniel N Bullock; Giulia Bertò; Guiomar Niso; Sandra Hanekamp; Daniel Levitas; Kimberly Ray; Anne MacKenzie; Paolo Avesani; Lindsey Kitchell; Josiah K Leong; Filipi Nascimento-Silva; Serge Koudoro; Hanna Willis; Jasleen K Jolly; Derek Pisner; Taylor R Zuidema; Jan W Kurzawski; Kyriaki Mikellidou; Aurore Bussalb; Maximilien Chaumon; Nathalie George; Christopher Rorden; Conner Victory; Dheeraj Bhatia; Dogu Baran Aydogan; Fang-Cheng F Yeh; Franco Delogu; Javier Guaje; Jelle Veraart; Jeremy Fischer; Joshua Faskowitz; Ricardo Fabrega; David Hunt; Shawn McKee; Shawn T Brown; Stephanie Heyman; Vittorio Iacovella; Amanda F Mejia; Daniele Marinazzo; R Cameron Craddock; Emanuale Olivetti; Jamie L Hanson; Eleftherios Garyfallidis; Dan Stanzione; James Carson; Robert Henschel; David Y Hancock; Craig A Stewart; David Schnyer; Damian O Eke; Russell A Poldrack; Steffen Bollmann; Ashley Stewart; Holly Bridge; Ilaria Sani; Winrich A Freiwald; Aina Puce; Nicholas L Port; Franco Pestilli

doi:10.1038/s41592-024-02237-2

brainlife.io: a decentralized and open-source cloud platform to support neuroscience research

Nat Methods. 2024 Apr 11. doi: 10.1038/s41592-024-02237-2. Online ahead of print.

Authors

Soichi Hayashi^#¹, Bradley A Caron^#^{1

2}, Anibal Sólon Heinsfeld², Sophia Vinci-Booher^{1

3}, Brent McPherson^{1

4}, Daniel N Bullock¹, Giulia Bertò², Guiomar Niso^{1

5}, Sandra Hanekamp², Daniel Levitas^{1

2}, Kimberly Ray², Anne MacKenzie², Paolo Avesani⁶, Lindsey Kitchell^{1

7}, Josiah K Leong^{1

8}, Filipi Nascimento-Silva¹, Serge Koudoro¹, Hanna Willis⁹, Jasleen K Jolly¹⁰, Derek Pisner², Taylor R Zuidema¹, Jan W Kurzawski¹¹, Kyriaki Mikellidou^{12

13}, Aurore Bussalb¹⁴, Maximilien Chaumon¹⁴, Nathalie George¹⁴, Christopher Rorden¹⁵, Conner Victory¹⁶, Dheeraj Bhatia², Dogu Baran Aydogan^{17

18}, Fang-Cheng F Yeh¹⁹, Franco Delogu¹⁶, Javier Guaje¹, Jelle Veraart¹¹, Jeremy Fischer¹, Joshua Faskowitz¹, Ricardo Fabrega¹, David Hunt¹, Shawn McKee²⁰, Shawn T Brown²¹, Stephanie Heyman²², Vittorio Iacovella²³, Amanda F Mejia¹, Daniele Marinazzo²⁴, R Cameron Craddock², Emanuale Olivetti²³, Jamie L Hanson¹⁹, Eleftherios Garyfallidis¹, Dan Stanzione², James Carson², Robert Henschel¹, David Y Hancock¹, Craig A Stewart¹, David Schnyer², Damian O Eke²⁵, Russell A Poldrack²⁶, Steffen Bollmann²⁷, Ashley Stewart²⁷, Holly Bridge⁹, Ilaria Sani^{28

29}, Winrich A Freiwald²⁸, Aina Puce¹, Nicholas L Port¹, Franco Pestilli^{30

31}

Affiliations

¹ Indiana University, Bloomington, IN, USA.
² The University of Texas, Austin, TX, USA.
³ Vanderbilt University, Nashville, TN, USA.
⁴ McGill University, Montréal, Quebec, Canada.
⁵ Cajal Institute, CSIC, Madrid, Spain.
⁶ Fondazione Bruno Kessler, Trento, Italy.
⁷ Applied Physics Laboratory, Johns Hopkins University, Laurel, MD, USA.
⁸ University of Arkansas, Fayetteville, AR, USA.
⁹ University of Oxford, Headington, Oxford, UK.
¹⁰ Anglia Ruskin University, Cambridge, UK.
¹¹ New York University, New York, NY, USA.
¹² University of Limassol, Nicosia, Cyprus.
¹³ University of Cyprus, Nicosia, Cyprus.
¹⁴ Institut du Cerveau, CNRS, Sorbonne Université, Paris, France.
¹⁵ University of South Carolina, Columbia, SC, USA.
¹⁶ Lawrence Technological University, Southfield, MI, USA.
¹⁷ University of Eastern Finland, Kuopio, Finland.
¹⁸ Aalto University School of Science, Espoo, Finland.
¹⁹ University of Pittsburgh, Pittsburgh, PA, USA.
²⁰ University of Michigan, Ann Arbor, MI, USA.
²¹ Hewlett-Packard Enterprise, Pittsburgh, PA, USA.
²² SHEGEL, Massul, Luxembourg.
²³ University of Trento, Rovereto, Italy.
²⁴ University of Ghent, Ghent, Belgium.
²⁵ University of Nottingham, Nottingham, UK.
²⁶ Stanford University, Stanford, CA, USA.
²⁷ University of Queensland, St Lucia, Queensland, Australia.
²⁸ The Rockefeller University, New York, NY, USA.
²⁹ University of Geneva, Geneva, Switzerland.
³⁰ Indiana University, Bloomington, IN, USA. pestilli@utexas.edu.
³¹ The University of Texas, Austin, TX, USA. pestilli@utexas.edu.

^# Contributed equally.

PMID: 38605111
DOI: 10.1038/s41592-024-02237-2

Abstract

Neuroscience is advancing standardization and tool development to support rigor and transparency. Consequently, data pipeline complexity has increased, hindering FAIR (findable, accessible, interoperable and reusable) access. brainlife.io was developed to democratize neuroimaging research. The platform provides data standardization, management, visualization and processing and automatically tracks the provenance history of thousands of data objects. Here, brainlife.io is described and evaluated for validity, reliability, reproducibility, replicability and scientific utility using four data modalities and 3,200 participants.

Abstract

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