Metabolic Imaging of Acute Ischemic Stroke (PET, 1Hydrogen Spectroscopy, 17Oxygen Imaging, 23Sodium MRI, pH Imaging)

Anil Vasireddi; Pamela W Schaefer; Saurabh Rohatgi

doi:10.1016/j.nic.2024.01.002

Metabolic Imaging of Acute Ischemic Stroke (PET, ¹Hydrogen Spectroscopy, ¹⁷Oxygen Imaging, ²³Sodium MRI, pH Imaging)

Neuroimaging Clin N Am. 2024 May;34(2):271-280. doi: 10.1016/j.nic.2024.01.002. Epub 2024 Feb 13.

Authors

Anil Vasireddi¹, Pamela W Schaefer², Saurabh Rohatgi²

Affiliations

¹ Division of Neuroradiology, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, Boston, MA 02114, USA. Electronic address: avasireddi@mgh.harvard.edu.
² Division of Neuroradiology, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, Boston, MA 02114, USA.

PMID: 38604711
DOI: 10.1016/j.nic.2024.01.002

Abstract

Acute stroke imaging plays a vital and time-sensitive role in therapeutic decision-making. Current clinical workflows widely use computed tomography (CT) and magnetic resonance (MR) techniques including CT and MR perfusion to estimate the volume of ischemic penumbra at risk for infarction without acute intervention. The use of imaging techniques aimed toward evaluating the metabolic derangements underlying a developing infarct may provide additional information for differentiating the penumbra from benign oligemia and infarct core. The authors review several modalities of metabolic imaging including PET, hydrogen and oxygen spectroscopy, sodium MRI, and pH-weighted MRI.

Keywords: Hydrogen spectroscopy; MRI; Metabolic imaging; Oxygen imaging; PET; Sodium MRI; Stroke; pH imaging.

Publication types

Review

MeSH terms

Brain Ischemia* / pathology
Humans
Hydrogen-Ion Concentration
Infarction
Ischemic Stroke*
Magnetic Resonance Imaging
Oxygen
Positron-Emission Tomography / methods
Spectrum Analysis
Stroke* / therapy

Substances

Oxygen