T1 mapping for head and neck Cancer patients undergoing Chemoradiotherapy: Feasibility of 3D stack of star imaging

Seong-Eun Kim; John A Roberts; Eugene G Kholmovski; Ying Hitchcock; Yoshimi Anzai

doi:10.1016/j.mri.2024.04.005

T1 mapping for head and neck Cancer patients undergoing Chemoradiotherapy: Feasibility of 3D stack of star imaging

Magn Reson Imaging. 2024 Apr 9:S0730-725X(24)00118-8. doi: 10.1016/j.mri.2024.04.005. Online ahead of print.

Authors

Seong-Eun Kim¹, John A Roberts², Eugene G Kholmovski³, Ying Hitchcock⁴, Yoshimi Anzai²

Affiliations

¹ Utah Center for Advanced Imaging Research, Department of Radiology, University of Utah, Salt Lake City, UT, USA. Electronic address: seongeun.kim@hsc.utah.edu.
² Utah Center for Advanced Imaging Research, Department of Radiology, University of Utah, Salt Lake City, UT, USA.
³ Utah Center for Advanced Imaging Research, Department of Radiology, University of Utah, Salt Lake City, UT, USA; Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, USA.
⁴ Department of Radiation Oncology, University of Utah, Salt Lake City, UT, USA.

PMID: 38604349
DOI: 10.1016/j.mri.2024.04.005

Abstract

Background: Measuring tissue oxygen concentration is crucial in understanding the pathophysiological process of hypoxia in head and neck cancer (HNC) and its significant role in cancer biology. This study aimed to determine the feasibility of T1 mapping using a variable flip angle (VFA) technique with stack of stars (SOS) trajectory sampling in HNC patients undergoing chemoradiotherapy (CRT).

Methods: To evaluate the ability of SOS acquisition to detect T1, a phantom study was conducted and compared to conventional Cartesian acquisition (CART). Additionally, four newly diagnosed patients were recruited and underwent two scans each at baseline and inter-treatment. The repeatability of SOS and CART acquisitions was assessed by comparing the T1 measurements of CSF from the baseline and intra-treatment MRI studies. The changes in ∆T1 of the tumors during air and oxygen inhalation between baseline and inter-treatment scans were also evaluated.

Results: Our study found that the 3D VFA SOS sequence was effective in reducing motion artifacts compared to the conventional VFA sequence with CART sampling and the same scan time, as demonstrated by the results from the phantom and patient studies. In terms of repeatability, no significant correlation was observed between the variability in ΔT1 measurements of CSF obtained from SOS T1 maps. The SOS ΔT1 measurements showed higher consistency, as evidenced by the ICC values ranging from 0.52 to 0.92. The ∆T1 measurements on the primary tumors increased after the first CRT (p<0.05) for all patients who showed a positive treatment response, except for one patient (0.05<p<0.1) who did not respond to the treatment.

Conclusion: The 3D VFA SOS sequence is a feasible and reliable method for T1 mapping in HNC patients undergoing CRT. The use of this technique could potentially aid in the assessment of treatment response and contribute to improving patient outcomes.

Keywords: 3D Stack of Star; Head and Neck Cancer; Oxygen-Enhancement; T1 measurements; Tumor Hypoxia; Variable Flip Angle Method.