Five undescribed cyclopeptides from Cordyceps militaris

Wei Yang; Cong Fu; Bin-Yuan Hu; Yong-Ming Yan; Yong-Xian Cheng

doi:10.1016/j.phytochem.2024.114074

Five undescribed cyclopeptides from Cordyceps militaris

Phytochemistry. 2024 Apr 10:222:114074. doi: 10.1016/j.phytochem.2024.114074. Online ahead of print.

Authors

Wei Yang¹, Cong Fu², Bin-Yuan Hu², Yong-Ming Yan², Yong-Xian Cheng³

Affiliations

¹ School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, 611137, PR China; Institute for Inheritance-Based Innovation of Chinese Medicine, Marshall Laboratory of Biomedical Engineering, School of Pharmacy, Shenzhen University Medical School, Shenzhen University, Shenzhen, 518055, PR China.
² Institute for Inheritance-Based Innovation of Chinese Medicine, Marshall Laboratory of Biomedical Engineering, School of Pharmacy, Shenzhen University Medical School, Shenzhen University, Shenzhen, 518055, PR China.
³ School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, 611137, PR China; Institute for Inheritance-Based Innovation of Chinese Medicine, Marshall Laboratory of Biomedical Engineering, School of Pharmacy, Shenzhen University Medical School, Shenzhen University, Shenzhen, 518055, PR China. Electronic address: yxcheng@szu.edu.cn.

PMID: 38604324
DOI: 10.1016/j.phytochem.2024.114074

Abstract

Ustiloxins I-M (1-5), five undescribed cyclopeptides bearing a 15-membered macrocyclic skeleton, were isolated from Cordyceps militaris. The structures of 1 and 5 were identified by spectroscopic and crystallographic methods, whereas the structures of 2-4 were assigned by spectroscopic and computational approaches. Biological evaluation of all the compounds toward human triple-negative breast cancer cells revealed that compounds 4 and 5 are toxic with IC₅₀ values of 64.29 μM and 28.89 μM, respectively.

Keywords: Clavicipitaceae; Cordyceps militaris; Cyclopeptides; Cytotoxic activity; Fungus.