Male infertility is one of the serious problems currently affecting human reproduction and health. Healthy gut microbiota is involved in the development of the immune system and protection against pathogen invasion, and it maintain normal metabolism and improve reproductive potential by secreting a variety of substances. The imbalance of gut microbiota can promote the local and systemic immune inflammatory response, induce chronic metabolic diseases, affect the synthesis of sex hormones, cause abnormal spermatogenesis, maturation or activation, and it is closely related to the decline of male fertility. By exploring the correlation between gut microbiota and male infertility, this paper aims to provide new clues and directions for the clinical diagnosis and treatment of male infertility.
Keywords: gut microbiota; male infertility; immune system; insulin resistance; semen quality.