Ironing out obesity

Gabriel O de Souza; Willian O Dos Santos; Jose Donato Jr

doi:10.1016/j.tem.2024.04.001

Ironing out obesity

Trends Endocrinol Metab. 2024 Apr 9:S1043-2760(24)00084-5. doi: 10.1016/j.tem.2024.04.001. Online ahead of print.

Authors

Gabriel O de Souza¹, Willian O Dos Santos¹, Jose Donato Jr²

Affiliations

¹ Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo 05508-000, Brazil.
² Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo 05508-000, Brazil. Electronic address: jdonato@icb.usp.br.

PMID: 38599900
DOI: 10.1016/j.tem.2024.04.001

Abstract

Obesity is associated with dysfunctions in hypothalamic neurons that regulate metabolism, including agouti-related protein (AgRP)-expressing neurons. In a recent article, Zhang et al. demonstrated that either diet- or genetically induced obesity promoted iron accumulation specifically in AgRP neurons. Preventing iron overload in AgRP neurons mitigated diet-induced obesity and related comorbidities in male mice.

Keywords: hypothalamus; insulin resistance; iron; leptin resistance; obesity.