Association Between Liver Fibrosis Score and Diabetic Kidney Disease: A Retrospective Cross-Sectional Study of Hospitalized Patients

Jie Zhang; Shen Chen; Zhendong Tian; Jiarui Cao; Yijie Jiao; Bangqi Wang; Shenghui Feng; Zhanpeng Luo; Qingfang Zhang; Yuanyuan Deng; Wei Cai; Jixiong Xu

doi:10.1055/a-2280-3742

Association Between Liver Fibrosis Score and Diabetic Kidney Disease: A Retrospective Cross-Sectional Study of Hospitalized Patients

Exp Clin Endocrinol Diabetes. 2024 Apr 10. doi: 10.1055/a-2280-3742. Online ahead of print.

Authors

Jie Zhang¹, Shen Chen^#², Zhendong Tian², Jiarui Cao², Yijie Jiao³, Bangqi Wang², Shenghui Feng², Zhanpeng Luo², Qingfang Zhang², Yuanyuan Deng¹, Wei Cai⁴, Jixiong Xu^{1

5

6}

Affiliations

¹ Department of Endocrinology and Metabolism, First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, 330006, People's Republic of China.
² Queen Mary School, Medical College, Nanchang University, Nanchang 330006, China.
³ The Third Clinical Medical School, Medical College, Nanchang University, Nanchang 330006, China.
⁴ Department of Medical Genetics and Cell biology, Medical College of Nanchang University, Nanchang, 330006, People's Republic of China.
⁵ Jiangxi Clinical Research Center for Endocrine and Metabolic Disease, Nanchang, Jiangxi, 330006, People's Republic of China.
⁶ Jiangxi Branch of National Clinical Research Center for Metabolic Disease, Nanchang, Jiangxi, 330006, People's Republic of China.

^# Contributed equally.

PMID: 38599609
DOI: 10.1055/a-2280-3742

Abstract

Objectives: To investigate the association between liver fibrosis score and diabetic kidney disease (DKD) in type 2 diabetes mellitus (T2DM).

Methods: A total of 897 hospitalized patients with T2DM were included in this study. Each patient completed DKD screening. Logistic regression analysis was used to assess the predictive value of non-alcoholic fatty liver disease fibrosis score (NAFLD-FS) and fibrosis-4 (FIB-4) for the occurrence of DKD and risk for DKD progression, respectively.

Results: The prevalence of DKD and risk for its progression significantly increased with increasing NAFLD-FS risk category. DKD prevalence also increased with increasing FIB-4 risk category. Multivariate logistic regression analysis showed that the "high-risk" NAFLD-FS had a significantly higher risk of DKD (odds ratio [OR]: 1.89, 95% confidence interval [CI]: 1.16-3.08) and risk for DKD progression (OR: 2.88, 95% CI: 1.23-6.78), and the "intermediate-risk" FIB-4 had a significantly higher risk of DKD (OR: 1.41, 95% CI: 1.00-1.98). Subgroup analysis showed that the association between NAFLD-FS and FIB-4 and DKD was significant in the female subgroup, whereas the association between the "high-risk" NAFLD-FS and risk for DKD progression was significant in the male subgroup.

Conclusions: NAFLD-FS and FIB-4 are strongly associated with DKD and risk for DKD progression in patients with T2DM. Additionally, sexual dimorphism exists in this association.