Relationship between the microenvironment and survival in kidney transplantation: a bibliometric analysis from 2013 to 2023

Chun-Lian Huang; Xin-Yu Fu; Yi Feng; Xiao-Kang Li; Yi Sun; Xin-Li Mao; Shao-Wei Li

doi:10.3389/fimmu.2024.1379742

Relationship between the microenvironment and survival in kidney transplantation: a bibliometric analysis from 2013 to 2023

Front Immunol. 2024 Mar 26:15:1379742. doi: 10.3389/fimmu.2024.1379742. eCollection 2024.

Authors

Chun-Lian Huang^#¹, Xin-Yu Fu^#², Yi Feng², Xiao-Kang Li^{3

4}, Yi Sun⁵, Xin-Li Mao^{3

6

7}, Shao-Wei Li^{3

6

7}

Affiliations

¹ Department of Infectious Diseases, Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University, Linhai, Zhejiang, China.
² Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University, Linhai, Zhejiang, China.
³ Key Laboratory of Minimally Invasive Techniques and Rapid Rehabilitation of Digestive System Tumor of Zhejiang Province, Linhai, Zhejiang, China.
⁴ Division of Transplantation Immunology, National Research Institute for Child Health and Development, Tokyo, Japan.
⁵ MRL Global Medical Affairs, MSD China, Shanghai, China.
⁶ Department of Gastroenterology, Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University, Linhai, Zhejiang, China.
⁷ Institute of Digestive Disease, Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University, Linhai, China.

^# Contributed equally.

Abstract

Background: Kidney transplantation is considered the most effective treatment for end-stage renal failure. Recent studies have shown that the significance of the immune microenvironment after kidney transplantation in determining prognosis of patients. Therefore, this study aimed to conduct a bibliometric analysis to provide an overview of the knowledge structure and research trends regarding the immune microenvironment and survival in kidney transplantation.

Methods: Our search included relevant publications from 2013 to 2023 retrieved from the Web of Science core repository and finally included 865 articles. To perform the bibliometric analysis, we utilized tools such as VOSviewer, CiteSpace, and the R package "bibliometrix". The analysis focused on various aspects, including country, author, year, topic, reference, and keyword clustering.

Results: Based on the inclusion criteria, a total of 865 articles were found, with a trend of steady increase. China and the United States were the countries with the most publications. Nanjing Medical University was the most productive institution. High-frequency keywords were clustered into 6 areas, including kidney transplantation, transforming growth factor β, macrophage, antibody-mediated rejection, necrosis factor alpha, and dysfunction. Antibody mediated rejection (2019-2023) was the main area of research in recent years.

Conclusion: This groundbreaking bibliometric study comprehensively summarizes the research trends and advances related to the immune microenvironment and survival after kidney transplantation. It identifies recent frontiers of research and highlights promising directions for future studies, potentially offering fresh perspectives to scholars in the field.

Keywords: CiteSpace; VOSview; bibliometrics; immune microenvironment; kidney transplantation; survival.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Antibodies
Bibliometrics
China
Cluster Analysis
Humans
Kidney Transplantation*

Substances

Antibodies

Grants and funding

The author(s) declare financial support was received for the research, authorship, and/or publication of this article. This work was supported by Medical Science and Technology Project of Zhejiang Province (2024KY1788), Major Research Program of Taizhou Enze Medical Center Grant (19EZZDA2), Program of Taizhou Science and Technology Grant (23ywa33), Open Project Program of Key Laboratory of Minimally Invasive Techniques and Rapid Rehabilitation of Digestive System Tumor of Zhejiang Province (21SZDSYS01&21SZDSYS09).