Harnessing oleaginous yeast to produce omega fatty acids

Lu Lin; Rodrigo Ledesma-Amaro; Xiao-Jun Ji; He Huang

doi:10.1016/j.tibtech.2024.03.005

Harnessing oleaginous yeast to produce omega fatty acids

Trends Biotechnol. 2024 Apr 9:S0167-7799(24)00084-2. doi: 10.1016/j.tibtech.2024.03.005. Online ahead of print.

Authors

Lu Lin¹, Rodrigo Ledesma-Amaro², Xiao-Jun Ji³, He Huang⁴

Affiliations

¹ State Key Laboratory of Materials-Oriented Chemical Engineering, College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, 30 South Puzhu Road, Nanjing 211816, PRC.
² Department of Bioengineering and Imperial College Centre for Synthetic Biology, Imperial College London, London SW7 2AZ, UK. Electronic address: r.ledesma-amaro@imperial.ac.uk.
³ State Key Laboratory of Materials-Oriented Chemical Engineering, College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, 30 South Puzhu Road, Nanjing 211816, PRC. Electronic address: xiaojunji@njtech.edu.cn.
⁴ State Key Laboratory of Materials-Oriented Chemical Engineering, College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, 30 South Puzhu Road, Nanjing 211816, PRC; School of Food Science and Pharmaceutical Engineering, Nanjing Normal University, 2 Xuelin Road, Nanjing 210023, PRC. Electronic address: huangh@njnu.edu.cn.

PMID: 38594144
DOI: 10.1016/j.tibtech.2024.03.005

Abstract

Omega fatty acids are important for human health. They are traditionally extracted from animals or plants but can be alternatively produced using oleaginous yeast. Current efforts are producing yeast strains with similar fatty acid distributions and powerful lipogenesis capacity. The next step is to further make the process more competitive.

Keywords: Yarrowia lipolytica; fatty acid profiles; lipogenesis; metabolic engineering; omega fatty acids; synthetic biology.