Diabetes and the fabkin complex: A dual-edged sword

Biochem Pharmacol. 2024 May:223:116196. doi: 10.1016/j.bcp.2024.116196. Epub 2024 Apr 6.

Abstract

The Fabkin complex, composed of FABP4, ADK, and NDPKs, emerges as a novel regulator of insulin-producing beta cells, offering promising prospects for diabetes treatment. Our approach, which combines literature review and database analysis, sets the stage for future research. These findings hold significant implications for both diabetes treatment and research, as they present potential therapeutic targets for personalized treatment, leading to enhanced patient outcomes and a deeper comprehension of the disease. The multifaceted role of the Fabkin complex in glucose metabolism, insulin resistance, anti-inflammation, beta cell proliferation, and vascular function underscores its therapeutic potential, reshaping diabetes management and propelling advancements in the field.

Keywords: ADK; Diabetes; FABP4; Fabkin; NDPK.

Publication types

  • Review

MeSH terms

  • Diabetes Mellitus* / drug therapy
  • Humans
  • Insulin Resistance*