The impact of menopause on antidepressant response: an explorative analysis from a real-world study

Matteo Carminati; Valentina Fazio; Melania Maccario; Raffaella Zanardi

doi:10.1007/s00737-024-01465-x

The impact of menopause on antidepressant response: an explorative analysis from a real-world study

Arch Womens Ment Health. 2024 Apr 8. doi: 10.1007/s00737-024-01465-x. Online ahead of print.

Authors

Matteo Carminati^#¹, Valentina Fazio^#², Melania Maccario^#², Raffaella Zanardi^#^{2

3}

Affiliations

¹ Department of Clinical Neurosciences, Vita-Salute San Raffaele University, Via Stamira d'Ancona, 20, 20127, Milan, Italy. carminati.matteo@hsr.it.
² Department of Clinical Neurosciences, Vita-Salute San Raffaele University, Via Stamira d'Ancona, 20, 20127, Milan, Italy.
³ Mood Disorder Unit, IRCCS San Raffaele Scientific Institute, Via Stamira d'Ancona, 20, 20127, Milan, Italy.

^# Contributed equally.

PMID: 38587634
DOI: 10.1007/s00737-024-01465-x

Abstract

This study endeavors to deepen our understanding of the subject matter by exploring, within a real-world sample, the impact of menopausal status on the antidepressant treatments response. The whole sample included a total of 447 patients, 156 male and 291 female, 110 pre-menopause and 181 post-menopause. In our sample post-menopause women showed a worse response to antidepressants than pre-menopause women (p = 0.006), and this difference seems to be unrelated to age or brain aging.

Keywords: Antidepressant response; Major depression; Menopause; Sex differences.