Melatonin receptor structure and signaling

Abstract

Melatonin (5-methoxy-N-acetyltryptamine) binds with high affinity and specificity to membrane receptors. Several receptor subtypes exist in different species, of which the mammalian MT₁ and MT₂ receptors are the best-characterized. They are members of the G protein-coupled receptor superfamily, preferentially coupling to G_i/o proteins but also to other G proteins in a cell-context-depending manner. In this review, experts on melatonin receptors will summarize the current state of the field. We briefly report on the discovery and classification of melatonin receptors, then focus on the molecular structure of human MT₁ and MT₂ receptors and highlight the importance of molecular simulations to identify new ligands and to understand the structural dynamics of these receptors. We then describe the state-of-the-art of the intracellular signaling pathways activated by melatonin receptors and their complexes. Brief statements on the molecular toolbox available for melatonin receptor studies and future perspectives will round-up this review.

Keywords: G protein‐coupled receptors; MT1; MT2; crystal structure; melatonin; melatonin receptors; molecular modeling; signaling.