Insights into the defensive roles of lncRNAs during Mycoplasma pneumoniae infection

Zhujun Yang; Junjun Zhou; Nana Su; Zifan Zhang; Jiaxin Chen; Peng Liu; Peng Ling

doi:10.3389/fmicb.2024.1330660

Insights into the defensive roles of lncRNAs during Mycoplasma pneumoniae infection

Front Microbiol. 2024 Mar 22:15:1330660. doi: 10.3389/fmicb.2024.1330660. eCollection 2024.

Authors

Zhujun Yang^{1

2}, Junjun Zhou^{1

2}, Nana Su^{1

2}, Zifan Zhang^{1

2}, Jiaxin Chen^{1

2}, Peng Liu^{1

2}, Peng Ling¹

Affiliations

¹ Department of Critical Care Medicine, The Central Hospital of Shaoyang City and Affiliated Shaoyang Hospital, Hengyang Medical College, University of South China, Shaoyang, China.
² Institute of Pathogenic Biology, Basic Medical School, Hengyang Medical School, University of South China, Hunan Provincial Key Laboratory for Special Pathogens Prevention and Control, Hengyang, China.

Abstract

Mycoplasma pneumoniae causes respiratory tract infections, affecting both children and adults, with varying degrees of severity ranging from mild to life-threatening. In recent years, a new class of regulatory RNAs called long non-coding RNAs (lncRNAs) has been discovered to play crucial roles in regulating gene expression in the host. Research on lncRNAs has greatly expanded our understanding of cellular functions involving RNAs, and it has significantly increased the range of functions of lncRNAs. In lung cancer, transcripts associated with lncRNAs have been identified as regulators of airway and lung inflammation in a process involving protein complexes. An excessive immune response and antibacterial immunity are closely linked to the pathogenesis of M. pneumoniae. The relationship between lncRNAs and M. pneumoniae infection largely involves lncRNAs that participate in antibacterial immunity. This comprehensive review aimed to examine the dysregulation of lncRNAs during M. pneumoniae infection, highlighting the latest advancements in our understanding of the biological functions and molecular mechanisms of lncRNAs in the context of M. pneumoniae infection and indicating avenues for investigating lncRNAs-related therapeutic targets.

Keywords: Mycoplasma pneumoniae; Mycoplasma pneumoniae infection; lncRNAs; lncRNAs functions; regulatory mechanism of lncRNAs.

Publication types

Review

Grants and funding

The author(s) declare that financial support was received for the research, authorship, and/or publication of this article. This research was supported by the Natural Science Foundation of Hunan Province, China (2023JJ30503); Research Foundation of Education Bureau of Hunan Province, China (22A0297); Research Foundation of University of South China (190XQD015); and Hunan Provincial College Students’ Innovation and Entrepreneurship Training Program (2022X10555197).