Effect of traditional Chinese medicine on metabolism disturbance in ischemic heart diseases

Anpei Wang; Qiubin Song; Yi Li; Hai Fang; Xiaoji Ma; Yunxia Li; Bo Wei; Chengxue Pan

doi:10.1016/j.jep.2024.118143

Effect of traditional Chinese medicine on metabolism disturbance in ischemic heart diseases

J Ethnopharmacol. 2024 Apr 5:329:118143. doi: 10.1016/j.jep.2024.118143. Online ahead of print.

Authors

Anpei Wang¹, Qiubin Song¹, Yi Li¹, Hai Fang¹, Xiaoji Ma¹, Yunxia Li¹, Bo Wei², Chengxue Pan³

Affiliations

¹ Key Laboratory of Advanced Drug Preparation Technologies, Ministry of Education, School of Pharmaceutical Sciences, Zhengzhou University, No. 100 Kexue Avenue, Zhengzhou, Henan, 450001, PR China.
² Key Laboratory of Advanced Drug Preparation Technologies, Ministry of Education, School of Pharmaceutical Sciences, Zhengzhou University, No. 100 Kexue Avenue, Zhengzhou, Henan, 450001, PR China. Electronic address: weibo@zzu.edu.cn.
³ Key Laboratory of Advanced Drug Preparation Technologies, Ministry of Education, School of Pharmaceutical Sciences, Zhengzhou University, No. 100 Kexue Avenue, Zhengzhou, Henan, 450001, PR China. Electronic address: pancx@zzu.edu.cn.

PMID: 38583735
DOI: 10.1016/j.jep.2024.118143

Abstract

Ethnopharmacological relevance: Ischemic heart diseases (IHD), characterized by metabolic dysregulation, contributes majorly to the global morbidity and mortality. Glucose, lipid and amino acid metabolism are critical energy production for cardiomyocytes, and disturbances of these metabolism lead to the cardiac injury. Traditional Chinese medicine (TCM), widely used for treating IHD, have been demonstrated to effectively and safely regulate the cardiac metabolism reprogramming.

Aim of the review: This study discussed and analyzed the disturbed cardiac metabolism induced by IHD and development of formulas, extracts, single herb, bioactive compounds of TCM ameliorating IHD injury via metabolism regulation, with the aim of providing a basis for the development of clinical application of therapeutic strategies for TCM in IHD.

Materials and methods: With "ischemic heart disease", "myocardial infarction", "myocardial ischemia", "metabolomics", "Chinese medicine", "herb", "extracts" "medicinal plants", "glucose", "lipid metabolism", "amino acid" as the main keywords, PubMed, Web of Science, and other online search engines were used for literature retrieval.

Results: IHD exhibits a close association with metabolism disorders, including but not limited to glycolysis, the TCA cycle, oxidative phosphorylation, branched-chain amino acids, fatty acid β-oxidation, ketone body metabolism, sphingolipid and glycerol-phospholipid metabolism. The therapeutic potential of TCM lies in its ability to regulate these disturbed cardiac metabolisms. Additionally, the active ingredients of TCM have depicted wonderful effects in cardiac metabolism reprogramming in IHD.

Conclusion: Drawing from the principles of TCM, we have pinpointed specific herbal remedies for the treatment of IHD, and leveraged advanced metabolomics technologies to uncover the effect of these TCMs on metabolomics alteration. In the future, further clinical experimental studies should be included to explore whether more TCM medicines can play a therapeutic role in IHD by reversing cardiac metabolism disorders; multi-omics would be conducted to explore more pathways and genes targeting such metabolism reprogramming by TCMs, and to seek more TCM therapies for IHD.

Keywords: Ischemic heart diseases; Mechanism; Metabolism disturbance; Metabolomics; Traditional Chinese medicine.

Publication types

Review