Diterpenoid glucosides with anti-inflammatory activity from Sigesbeckia glabrescens

Lian-Yu Tang; Ya-Zhao Zhang; Yun Gao; Tashi Tsering; Jingming Jia; Anhua Wang

doi:10.1016/j.fitote.2024.105954

Diterpenoid glucosides with anti-inflammatory activity from Sigesbeckia glabrescens

Fitoterapia. 2024 Apr 6:175:105954. doi: 10.1016/j.fitote.2024.105954. Online ahead of print.

Authors

Lian-Yu Tang¹, Ya-Zhao Zhang¹, Yun Gao¹, Tashi Tsering², Jingming Jia³, Anhua Wang⁴

Affiliations

¹ School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, People's Republic of China.
² Traditional Tibetan Medical Research & Study Institute of Regional Traditional Tibetan Medical Hospital, Lhasa, People's Republic of China. Electronic address: zhaxi75@126.com.
³ School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, People's Republic of China. Electronic address: jiajingming@163.com.
⁴ School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, People's Republic of China. Electronic address: sywanganhua@163.com.

PMID: 38583638
DOI: 10.1016/j.fitote.2024.105954

Abstract

Six previously undescribed diterpenoid glucosides, along with four known compounds, were isolated from the aerial parts of Sigesbeckia glabrescens. The structures and absolute configurations of undescribed compounds were elucidated using extensive spectroscopic techniques, ECD calculations and chemical methods. Compounds 1 and 8 exhibited anti-inflammatory activity against LPS-induced NO production in RAW 264.7 macrophages, with compound 8 demonstrating significant inhibitory activity compared to positive control minocycline, boasting an IC₅₀ value at 14.20 μM.

Keywords: Anti-inflammatory activity; Asteracrar; Diterpenoid glycosides; Sigesbeckia glabrescens.