New nanosensor fabricated on single nanopore electrode filled with prussian blue and graphene quantum dots coated by polypyrrole for hydrogen peroxide sensing

Xiaohu Chen; Qingshan Dai; Xia Qiu; Xianzhun Luo; Yongxin Li

doi:10.1016/j.talanta.2024.126043

New nanosensor fabricated on single nanopore electrode filled with prussian blue and graphene quantum dots coated by polypyrrole for hydrogen peroxide sensing

Talanta. 2024 Jul 1:274:126043. doi: 10.1016/j.talanta.2024.126043. Epub 2024 Apr 3.

Authors

Xiaohu Chen¹, Qingshan Dai¹, Xia Qiu¹, Xianzhun Luo¹, Yongxin Li²

Affiliations

¹ Anhui Province Key Laboratory of Biomedical Materials and Chemical Measurement, Key Laboratory of Functional Molecular Solids, Ministry of Education, College of Chemistry and Materials Science, Anhui Normal University, Wuhu, 241000, PR China.
² Anhui Province Key Laboratory of Biomedical Materials and Chemical Measurement, Key Laboratory of Functional Molecular Solids, Ministry of Education, College of Chemistry and Materials Science, Anhui Normal University, Wuhu, 241000, PR China. Electronic address: yongli@mail.ahnu.edu.cn.

PMID: 38581852
DOI: 10.1016/j.talanta.2024.126043

Abstract

Hydrogen peroxide (H₂O₂) is a common oxidant that plays an important role in many biological processes and is also an important medium analysis in various fields. In this work, a new electrochemical nanosensor capable of detecting and quantifying hydrogen peroxide was introduced. This nanosensor was fabricated by electrodepositing prussian blue (PB)/graphene quantum dots (GQDs)/polypyrrole (PPy) on single nanopore electrode etched from single gold nanoelectrode. This prepapred nanosensor exhibits good electrochemical response to hydrogen peroxide with high sensitivity and stability, with a linear response in the 2.0 and 80 μM by using amperometric method and differential pulse voltammetry (DPV) method. The limit of detections are 0.33 μM (S/N = 3) for amperometric method and 0.67 μM (S/N = 3) for differential pulse voltammetry (DPV) method, respectively. This nanosensor can be used for the determination of hydrogen peroxide in human urine, and can serve as a new electrochemical platform to monitor H₂O₂ release from single living cells due to its small overal dimension and high sensitivity.