Cancer immunometabolism: advent, challenges, and perspective

Qin Dang; Borui Li; Bing Jin; Zeng Ye; Xin Lou; Ting Wang; Yan Wang; Xuan Pan; Qiangsheng Hu; Zheng Li; Shunrong Ji; Chenjie Zhou; Xianjun Yu; Yi Qin; Xiaowu Xu

doi:10.1186/s12943-024-01981-5

Cancer immunometabolism: advent, challenges, and perspective

Mol Cancer. 2024 Apr 5;23(1):72. doi: 10.1186/s12943-024-01981-5.

Authors

Qin Dang^#^{1

2

3

4}, Borui Li^#^{1

2

3

4}, Bing Jin^#⁵, Zeng Ye^{1

2

3

4}, Xin Lou^{1

2

3

4}, Ting Wang^{1

2

3

4}, Yan Wang^{1

2

3

4}, Xuan Pan⁶, Qiangsheng Hu⁷, Zheng Li^{1

2

3

4}, Shunrong Ji^{1

2

3

4}, Chenjie Zhou^{1

2

3

4}, Xianjun Yu^{8

9

10

11}, Yi Qin^{12

13

14

15}, Xiaowu Xu^{16

17

18

19}

Affiliations

¹ Department of Pancreatic Surgery, Fudan University Shanghai Cancer Center, Shanghai, China.
² Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China.
³ Shanghai Pancreatic Cancer Institute, Shanghai, China.
⁴ Pancreatic Cancer Institute, Fudan University, Shanghai, China.
⁵ School of Clinical Medicine, Zhengzhou University, Zhengzhou, China.
⁶ Department of Hepatobiliary Surgery, Yijishan Hospital, The First Affiliated Hospital of Wannan Medical College, Wuhu, China.
⁷ Department of Thoracic Surgery, Shanghai Pulmonary Hospital, Tongji University, Shanghai, China.
⁸ Department of Pancreatic Surgery, Fudan University Shanghai Cancer Center, Shanghai, China. yuxianjun@fudanpci.org.
⁹ Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China. yuxianjun@fudanpci.org.
¹⁰ Shanghai Pancreatic Cancer Institute, Shanghai, China. yuxianjun@fudanpci.org.
¹¹ Pancreatic Cancer Institute, Fudan University, Shanghai, China. yuxianjun@fudanpci.org.
¹² Department of Pancreatic Surgery, Fudan University Shanghai Cancer Center, Shanghai, China. qinyi@fudanpci.org.
¹³ Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China. qinyi@fudanpci.org.
¹⁴ Shanghai Pancreatic Cancer Institute, Shanghai, China. qinyi@fudanpci.org.
¹⁵ Pancreatic Cancer Institute, Fudan University, Shanghai, China. qinyi@fudanpci.org.
¹⁶ Department of Pancreatic Surgery, Fudan University Shanghai Cancer Center, Shanghai, China. xuxiaowu@fudanpci.org.
¹⁷ Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China. xuxiaowu@fudanpci.org.
¹⁸ Shanghai Pancreatic Cancer Institute, Shanghai, China. xuxiaowu@fudanpci.org.
¹⁹ Pancreatic Cancer Institute, Fudan University, Shanghai, China. xuxiaowu@fudanpci.org.

^# Contributed equally.

Abstract

For decades, great strides have been made in the field of immunometabolism. A plethora of evidence ranging from basic mechanisms to clinical transformation has gradually embarked on immunometabolism to the center stage of innate and adaptive immunomodulation. Given this, we focus on changes in immunometabolism, a converging series of biochemical events that alters immune cell function, propose the immune roles played by diversified metabolic derivatives and enzymes, emphasize the key metabolism-related checkpoints in distinct immune cell types, and discuss the ongoing and upcoming realities of clinical treatment. It is expected that future research will reduce the current limitations of immunotherapy and provide a positive hand in immune responses to exert a broader therapeutic role.

Keywords: Cancer-immunity cycle; Cancer-immunometabolism subcycle; Immunity; Immunometabolism; Metabolic adaptation; Metabolic reprogramming.

Publication types

Review

MeSH terms

Humans
Immunity*
Immunomodulation
Immunotherapy
Neoplasms* / therapy

Abstract

Publication types

MeSH terms

Grants and funding