The role of vasculature and angiogenesis in respiratory diseases

Maximilian Ackermann; Christopher Werlein; Edith Plucinski; Sophie Leypold; Mark P Kühnel; Stijn E Verleden; Hassan A Khalil; Florian Länger; Tobias Welte; Steven J Mentzer; Danny D Jonigk

doi:10.1007/s10456-024-09910-2

The role of vasculature and angiogenesis in respiratory diseases

Angiogenesis. 2024 Apr 5. doi: 10.1007/s10456-024-09910-2. Online ahead of print.

Authors

Maximilian Ackermann^{1

2

3}, Christopher Werlein⁴, Edith Plucinski⁴, Sophie Leypold⁵, Mark P Kühnel^{5

6}, Stijn E Verleden⁷, Hassan A Khalil^{8

9}, Florian Länger⁵, Tobias Welte^{6

10}, Steven J Mentzer^{8

9}, Danny D Jonigk^{5

6}

Affiliations

¹ Institute of Pathology, University Clinics of RWTH University, Aachen, Germany. maximilian.ackermann@uni-mainz.de.
² Institute of Pathology and Molecular Pathology, Helios University Clinic Wuppertal, University of Witten/Herdecke, Witten, Germany. maximilian.ackermann@uni-mainz.de.
³ Institute of Anatomy, University Medical Center of the Johannes Gutenberg-University, Mainz, Germany. maximilian.ackermann@uni-mainz.de.
⁴ Institute of Pathology, Hannover Medical School, Hannover, Germany.
⁵ Institute of Pathology, University Clinics of RWTH University, Aachen, Germany.
⁶ Member of the German Center for Lung Research (DZL), Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), Hannover, Germany.
⁷ Antwerp Surgical Training, Anatomy and Research Centre (ASTARC), University of Antwerp, Antwerp, Belgium.
⁸ Division of Thoracic and Cardiac Surgery, Department of Surgery, Brigham and Women's Hospital, Boston, USA.
⁹ Laboratory of Adaptive and Regenerative Biology, Brigham & Women's Hospital, Harvard Medical School, Boston, MA, USA.
¹⁰ Department of Respiratory Medicine, Hannover Medical School, Hannover, Germany.

PMID: 38580869
DOI: 10.1007/s10456-024-09910-2

Abstract

In European countries, nearly 10% of all hospital admissions are related to respiratory diseases, mainly chronic life-threatening diseases such as COPD, pulmonary hypertension, IPF or lung cancer. The contribution of blood vessels and angiogenesis to lung regeneration, remodeling and disease progression has been increasingly appreciated. The vascular supply of the lung shows the peculiarity of dual perfusion of the pulmonary circulation (vasa publica), which maintains a functional blood-gas barrier, and the bronchial circulation (vasa privata), which reveals a profiled capacity for angiogenesis (namely intussusceptive and sprouting angiogenesis) and alveolar-vascular remodeling by the recruitment of endothelial precursor cells. The aim of this review is to outline the importance of vascular remodeling and angiogenesis in a variety of non-neoplastic and neoplastic acute and chronic respiratory diseases such as lung infection, COPD, lung fibrosis, pulmonary hypertension and lung cancer.

Keywords: COPD; COVID-19; ECFC; Endothelial mesenchymal transition (EndoMT); Fibrovascular interface; Intussusceptive angiogenesis; Pulmonary fibrosis; Respiratory diseases; Tumor angiogenesis; Vascular normalization.

Publication types

Review

Abstract

Publication types

Grants and funding