Role of electrophysiological activity and interactions of lateral habenula in the development of depression-like behavior in a chronic restraint stress model

Chang Wang; Yuting Sun; Yanjie Xing; Kezhou Liu; Kedi Xu

doi:10.1016/j.brainres.2024.148914

Role of electrophysiological activity and interactions of lateral habenula in the development of depression-like behavior in a chronic restraint stress model

Brain Res. 2024 Apr 3:1835:148914. doi: 10.1016/j.brainres.2024.148914. Online ahead of print.

Authors

Chang Wang¹, Yuting Sun², Yanjie Xing³, Kezhou Liu⁴, Kedi Xu⁵

Affiliations

¹ Qiushi Academy for Advanced Studies (QAAS), Zhejiang University, Hangzhou, China; Nanhu Brain-computer Interface Institute, Hangzhou 311100,China; Zhejiang Provincial Key Laboratory of Cardio-Cerebral Vascular Detection Technology and Medicinal Effectiveness Appraisal, Key Laboratory of Biomedical Engineering of Education Ministry, Department of Biomedical Engineering, Zhejiang University, Hangzhou, China; State Key Lab of Brain-Machine Intelligence, Zhejiang University, Hangzhou, China. Electronic address: wangchang0421@zju.edu.cn.
² Qiushi Academy for Advanced Studies (QAAS), Zhejiang University, Hangzhou, China; Nanhu Brain-computer Interface Institute, Hangzhou 311100,China; Zhejiang Provincial Key Laboratory of Cardio-Cerebral Vascular Detection Technology and Medicinal Effectiveness Appraisal, Key Laboratory of Biomedical Engineering of Education Ministry, Department of Biomedical Engineering, Zhejiang University, Hangzhou, China; State Key Lab of Brain-Machine Intelligence, Zhejiang University, Hangzhou, China. Electronic address: sunyt@zju.edu.cn.
³ Qiushi Academy for Advanced Studies (QAAS), Zhejiang University, Hangzhou, China; Nanhu Brain-computer Interface Institute, Hangzhou 311100,China; Zhejiang Provincial Key Laboratory of Cardio-Cerebral Vascular Detection Technology and Medicinal Effectiveness Appraisal, Key Laboratory of Biomedical Engineering of Education Ministry, Department of Biomedical Engineering, Zhejiang University, Hangzhou, China; State Key Lab of Brain-Machine Intelligence, Zhejiang University, Hangzhou, China. Electronic address: xingyj@zju.edu.cn.
⁴ School of Automation (Artificial Intelligence), Hangzhou Dianzi University, Hangzhou 310018, China. Electronic address: liukezhou@hdu.edu.cn.
⁵ Qiushi Academy for Advanced Studies (QAAS), Zhejiang University, Hangzhou, China; Nanhu Brain-computer Interface Institute, Hangzhou 311100,China; Zhejiang Provincial Key Laboratory of Cardio-Cerebral Vascular Detection Technology and Medicinal Effectiveness Appraisal, Key Laboratory of Biomedical Engineering of Education Ministry, Department of Biomedical Engineering, Zhejiang University, Hangzhou, China; State Key Lab of Brain-Machine Intelligence, Zhejiang University, Hangzhou, China. Electronic address: xukd@zju.edu.cn.

PMID: 38580047
DOI: 10.1016/j.brainres.2024.148914

Abstract

Closed-loop deep brain stimulation (DBS) system offers a promising approach for treatment-resistant depression, but identifying universally accepted electrophysiological biomarkers for closed-loop DBS systems targeting depression is challenging. There is growing evidence suggesting a strong association between the lateral habenula (LHb) and depression. Here, we took LHb as a key target, utilizing multi-site local field potentials (LFPs) to study the acute and chronic changes in electrophysiology, functional connectivity, and brain network characteristics during the formation of a chronic restraint stress (CRS) model. Furthermore, our model combining the electrophysiological changes of LHb and interactions between LHb and other potential targets of depression can effectively distinguish depressive states, offering a new way for developing effective closed-loop DBS strategies.

Keywords: Chronic restraint stress; Depression; Functional Connectivity; Graph theory; Lateral habenula; Local field potential.