Changing structures, changing paradigms: NELF helps regulate paused or elongating RNA polymerase II

William F Richter; Dylan J Taatjes

doi:10.1016/j.molcel.2024.03.008

Changing structures, changing paradigms: NELF helps regulate paused or elongating RNA polymerase II

Mol Cell. 2024 Apr 4;84(7):1180-1182. doi: 10.1016/j.molcel.2024.03.008.

Authors

William F Richter¹, Dylan J Taatjes²

Affiliations

¹ Department of Biochemistry, University of Colorado, Boulder, CO 80303, USA.
² Department of Biochemistry, University of Colorado, Boulder, CO 80303, USA. Electronic address: taatjes@colorado.edu.

PMID: 38579674
DOI: 10.1016/j.molcel.2024.03.008

Abstract

Using cryo-EM and biochemical methods, Su and Vos¹ discover an alternative NELF structural state that enables transcription and switches NELF-RNA polymerase II (RNAPII) compatibility with other RNAPII-associated factors that regulate pausing, elongation, termination, and transcription-coupled DNA repair.

Publication types

News

MeSH terms

Promoter Regions, Genetic
RNA Polymerase II* / genetics
RNA Polymerase II* / metabolism
Transcription Factors* / genetics
Transcription Factors* / metabolism
Transcription, Genetic

Substances

RNA Polymerase II
Transcription Factors
NSMF protein, human