Essential data variables for a minimum dataset for head and neck cancer trials and clinical research: HNCIG consensus recommendations and database

Sujith Baliga; Ahmad K Abou-Foul; Pablo Parente; Petr Szturz; Juliette Thariat; Aditya Shreenivas; Paul Nankivell; Federica Bertolini; Julian Biau; Dukagjin Blakaj; Sinead Brennan; Aina Brunet; Thiago Bueno De Oliveira; Barbara Burtness; Alberto Carral Maseda; Velda Ling-Yu Chow; Melvin Lk Chua; Mischa de Ridder; Satya Garikipati; Nobuhiro Hanai; Francis Cho Hao Ho; Shao Hui Huang; Naomi Kiyota; Konrad Klinghammer; Luiz P Kowalski; Dora L Kwong; Lachlan J McDowell; Marco Carlo Merlano; Sudhir Nair; Panagiota Economopoulou; Jens Overgaard; Amanda Psyrri; Silke Tribius; John Waldron; Sue S Yom; Hisham Mehanna

doi:10.1016/j.ejca.2024.114038

Essential data variables for a minimum dataset for head and neck cancer trials and clinical research: HNCIG consensus recommendations and database

Eur J Cancer. 2024 May:203:114038. doi: 10.1016/j.ejca.2024.114038. Epub 2024 Mar 30.

Authors

Sujith Baliga¹, Ahmad K Abou-Foul², Pablo Parente³, Petr Szturz⁴, Juliette Thariat⁵, Aditya Shreenivas⁶, Paul Nankivell⁷, Federica Bertolini⁸, Julian Biau⁹, Dukagjin Blakaj¹⁰, Sinead Brennan¹¹, Aina Brunet¹², Thiago Bueno De Oliveira¹³, Barbara Burtness¹⁴, Alberto Carral Maseda¹⁵, Velda Ling-Yu Chow¹⁶, Melvin Lk Chua¹⁷, Mischa de Ridder¹⁸, Satya Garikipati¹⁹, Nobuhiro Hanai²⁰, Francis Cho Hao Ho²¹, Shao Hui Huang²², Naomi Kiyota²³, Konrad Klinghammer²⁴, Luiz P Kowalski²⁵, Dora L Kwong²⁶, Lachlan J McDowell²⁷, Marco Carlo Merlano²⁸, Sudhir Nair²⁹, Panagiota Economopoulou³⁰, Jens Overgaard³¹, Amanda Psyrri³², Silke Tribius³³, John Waldron³⁴, Sue S Yom³⁵, Hisham Mehanna³⁶

Affiliations

¹ Department of Radiation Oncology, The Ohio State University Wexner Medical Center, Columbus, OH, USA. Electronic address: Sujith.baliga@osumc.edu.
² Institute for Head and neck studies and education, University of Birmingham, UK. Electronic address: a.abou-foul@bham.ac.uk.
³ Department of Otolaryngology and Head and Neck Surgery, Hospital Universitario Lucus Augusti, Lugo, Spain. Electronic address: plparente@gmail.com.
⁴ Medical Oncology, Department of Oncology, Lausanne University Hospital (CHUV), 1011 Lausanne, Switzerland; Faculty of Biology and Medicine, University of Lausanne (UNIL), 1011 Lausanne, Switzerland. Electronic address: szturz@gmail.com.
⁵ Department of Radiation Oncology, Comprehensive Cancer Centre François Baclesse, Caen, France. Electronic address: jthariat@gmail.com.
⁶ Department of Hematology and Oncology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA. Electronic address: ashreenivas@mcw.edu.
⁷ Institute for Head and Neck Studies and Education, University of Birmingham, UK. Electronic address: p.c.nankivell@bham.ac.uk.
⁸ Department of oncology, Modena University Hospital, Modena, Italy. Electronic address: bertolini.federica@aou.mo.it.
⁹ INSERM U1240 IMoST, University of Clermont Auvergne, Clermont-Ferrand, France; Department of radiation therapy, Centre Jean Perrin, Clermont-Ferrand, France, University of Clermont Auvergne, Clermont-Ferrand, France. Electronic address: julian.biau@clermont.unicancer.fr.
¹⁰ Ohio State University, OH, USA. Electronic address: Blakaj.1@osu.edu.
¹¹ St Luke's Radiation Oncology Network, Dublin, Ireland. Electronic address: Sinead.brennan@slh.ie.
¹² Department of Otorhinolaryngology and Head and Neck Surgery, Hospital Universitari Bellvitge, Institut d'Investigacio Biomedica (IDIBELL), Barcelona, Spain. Electronic address: brunetain@gmail.com.
¹³ AC Camargo Cancer Center, Sao Paulo, Brazil. Electronic address: thiagobueno32@yahoo.com.br.
¹⁴ Department of Internal Medicine and Yale Cancer Center, Yale School of Medicine, CT, USA. Electronic address: barbara.burtness@yale.edu.
¹⁵ Lucus Augusti University Hospital, Lugo, Spain. Electronic address: alberto_carral@hotmail.com.
¹⁶ Department of Surgery, The University of Hong Kong, Hong Kong, SAR China. Electronic address: vlychow@gmail.com.
¹⁷ Oncology Academic Programme, Duke-NUS Medical School, Singapore; Division of Radiation Oncology, National Cancer Centre Singapore, Duke-NUS Medical School, Singapore. Electronic address: gmsclkm@nus.edu.sg.
¹⁸ Department of radiotherapy, University Medical Center Utrecht, the Netherlands. Electronic address: M.deridder-5@umcutrecht.nl.
¹⁹ Sheffield Teaching Hospitals NHS Trust, Sheffield, UK. Electronic address: s.garikipati@nhs.net.
²⁰ Department of Head and Neck Surgery, Aichi Cancer Center Hospital, Aichi, Japan. Electronic address: hanai@aichi-cc.jp.
²¹ National University Cancer Institute, Singapore. Electronic address: Francisho@nus.edu.sg.
²² Department of Radiation Oncology, Princess Margaret Cancer Centre / University of Toronto, Tornoto, Canada. Electronic address: shaohui.huang@rmp.uhn.ca.
²³ Cancer Center, Kobe Univesity Hospital, Kobe, Japan. Electronic address: nkiyota@med.kobe-u.ac.jp.
²⁴ Department of Hematology, Oncology and Cancer Immunology, Campus Benjamin Franklin Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin Hindenburgdamm, Berlin, Germany. Electronic address: Konrad.klinghammer@charite.de.
²⁵ Department of Head and Neck Surgery, University of São Paulo Medical School, São Paulo, Brazil; Department of Head and Neck Surgery and Otorhinolaryngology, A C Camargo Cancer Center, São Paulo, Brazil. Electronic address: lp_kowalski@uol.com.br.
²⁶ Department of Clinical Oncology, Centre of Cancer Medicine, School of Clinical Medicine, LSK Faculty of Medicine, the University of Hong Kong, Hong Kong, SAR China. Electronic address: dlwkwong@hku.hk.
²⁷ Faculty of Medicine, University of Queensland, Brisbane, Australia; Department of Radiation Oncology, Princess Alexandra Hospital, Woollongabba, Australia, University of Queensland, Brisbane, Australia. Electronic address: lachlan.mcdowell@health.qld.gov.au.
²⁸ Scientific Direction, Candiolo Cancer Center, FPO-IRCCS, Candiolo, Italy. Electronic address: mcmerlano@gmail.com.
²⁹ Department of Surgical Oncology, Advanced Centre for Treatment, Research and Education in Cancer, Tata Memorial Centre, Mumbai, India. Electronic address: Sudhirvr@gmail.com.
³⁰ Medical Oncology Unit, 2nd Department of Internal Medicine, Attikon University Hospital, National and Kapodistrian University of Athens, Athens, Greece. Electronic address: panagiota_oiko@hotmail.com.
³¹ Department of Experimental Clinical Oncology, Aarhus University Hospital, Denmark. Electronic address: jens@oncology.au.dk.
³² Medical Oncology Unit, 2nd Department of Internal Medicine, Attikon University Hospital, National and Kapodistrian University of Athens, Athens, Greece. Electronic address: dpsyrri@med.uoa.gr.
³³ Hermann, Holthusen Institute of Radiation Oncology Asklepios Klinik St. Georg Asklepios Tumorzentrum, Hamburg, Germany. Electronic address: s.tribius@asklepios.com.
³⁴ Princess Margaret Cancer Center University of Toronto, Canada. Electronic address: john.waldron@rmp.uhn.ca.
³⁵ University of California San Francisco, San Francisco, CA, USA. Electronic address: sue.yom@ucsf.edu.
³⁶ Institute for Head and neck studies and education, University of Birmingham, Birmingham, UK. Electronic address: h.mehanna@bham.ac.uk.

PMID: 38579517
DOI: 10.1016/j.ejca.2024.114038

Abstract

The Head and Neck Cancer International Group (HNCIG) has undertaken an international modified Delphi process to reach consensus on the essential data variables to be included in a minimum database for HNC research. Endorsed by 19 research organisations representing 34 countries, these recommendations provide the framework to facilitate and harmonise data collection and sharing for HNC research. These variables have also been incorporated into a ready to use downloadable HNCIG minimum database, available from the HNCIG website.

Keywords: Cancer database; Collaborative research; Data harmonisation; Head and Neck cancer; Head and neck squamous cell carcinoma.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Biomedical Research / standards
Clinical Trials as Topic* / standards
Consensus*
Databases, Factual* / standards
Delphi Technique
Head and Neck Neoplasms* / therapy
Humans