Modular-integrative modeling: a new framework for building brain models that blend biological realism and functional performance

Mario Senden; Sacha J van Albada; Giovanni Pezzulo; Egidio Falotico; Ibrahim Hashim; Alexander Kroner; Anno C Kurth; Pablo Lanillos; Vaishnavi Narayanan; Cyriel Pennartz; Mihai A Petrovici; Lea Steffen; Tonio Weidler; Rainer Goebel

doi:10.1093/nsr/nwad318

Modular-integrative modeling: a new framework for building brain models that blend biological realism and functional performance

Natl Sci Rev. 2023 Dec 20;11(5):nwad318. doi: 10.1093/nsr/nwad318. eCollection 2024 May.

Authors

Mario Senden^{1

2}, Sacha J van Albada^{3

4}, Giovanni Pezzulo⁵, Egidio Falotico⁶, Ibrahim Hashim^{1

2}, Alexander Kroner^{1

2}, Anno C Kurth^{3

7}, Pablo Lanillos⁸, Vaishnavi Narayanan^{1

2}, Cyriel Pennartz⁹, Mihai A Petrovici¹⁰, Lea Steffen¹¹, Tonio Weidler^{1

2}, Rainer Goebel^{1

2}

Affiliations

¹ Department of Cognitive Neuroscience, Maastricht University, The Netherlands.
² Maastricht Brain Imaging Centre, Maastricht University, The Netherlands.
³ Institute of Neuroscience and Medicine (INM-6) and Institute for Advanced Simulation (IAS-6) and JARA-Institut Brain Structure-Function Relationships (INM-10), Jülich Research Center, Germany.
⁴ Institute of Zoology, University of Cologne, Germany.
⁵ Institute of Cognitive Sciences and Technologies, National Research Council, Italy.
⁶ The BioRobotics Institute, Scuola Superiore Sant'Anna, Italy.
⁷ RWTH Aachen University, Germany.
⁸ Donders Institute for Brain, Cognition and Behavior, Radboud University, The Netherlands.
⁹ Cognitive and Systems Neuroscience Group, Swammerdam Institute for Life Sciences, University of Amsterdam, The Netherlands.
¹⁰ Department of Physiology, University of Bern, Switzerland.
¹¹ FZI Research Center of Information Technology, Germany.

Abstract

This Perspective presents the Modular-Integrative Modeling approach, a novel framework in neuroscience for developing brain models that blend biological realism with functional performance to provide a holistic view on brain function in interaction with the body and environment.