The regulatory process and practical significance of non-coding RNA in the dissemination of prostate cancer to the skeletal system

Hui Sang; Luxi Li; Qiang Zhao; Yulin Liu; Jinbo Hu; Peng Niu; Zhenming Hao; Keqiang Chai

doi:10.3389/fonc.2024.1358422

The regulatory process and practical significance of non-coding RNA in the dissemination of prostate cancer to the skeletal system

Front Oncol. 2024 Mar 21:14:1358422. doi: 10.3389/fonc.2024.1358422. eCollection 2024.

Authors

Hui Sang^#¹, Luxi Li^#¹, Qiang Zhao¹, Yulin Liu¹, Jinbo Hu¹, Peng Niu¹, Zhenming Hao¹, Keqiang Chai¹

Affiliation

¹ Department of Urology, The Third Affiliated Hospital of Gansu University of Traditional Chinese Medicine, Baiyin, China.

^# Contributed equally.

Abstract

Prostate cancer is a major contributor to male cancer-related mortality globally. It has a particular affinity for the skeletal system with metastasis to bones seriously impacting prognosis. The identification of prostate cancer biomarkers can significantly enhance diagnosis and patient monitoring. Research has found that cancer and metastases exhibit abnormal expression of numerous non-coding RNA. Some of these RNA facilitate prostate cancer bone metastasis by activating downstream signaling pathways, while others inhibit this process. Elucidating the functional processes of non-coding RNA in prostate cancer bone metastasis will likely lead to innovative treatment strategies for this malignant condition. In this review, the mechanistic role of the various RNA in prostate cancer is examined. Our goal is to provide a new avenue of approach to the diagnosis and treatment of bone metastasis in this cancer.

Keywords: bone metastasis; circular RNA; long non-coding RNA; micro RNA; non-coding RNA; prostate cancer; signaling pathway; targeted therapy.

Publication types

Review

Grants and funding

The author(s) declare financial support was received for the research, authorship, and/or publication of this article. This work was supported by Baiyin Science and Technology Plan Project (Clinical Application research on early screening of Prostate cancer in Baiyin Area: 2022-3-6Y) and Baiyin First People’s Hospital Science and Technology Plan Project (2019YK-08).