Biochemical Significance of miR-155 and miR-375 as Diagnostic Biomarkers and Their Correlation with the NF-κβ/TNF-α Axis in Breast Cancer

Sahar A Abdel-Samed; Walaa G Hozyen; Saeed M Shaaban; Nabil A Hasona

doi:10.1007/s12291-022-01101-4

Biochemical Significance of miR-155 and miR-375 as Diagnostic Biomarkers and Their Correlation with the NF-κβ/TNF-α Axis in Breast Cancer

Indian J Clin Biochem. 2024 Apr;39(2):226-232. doi: 10.1007/s12291-022-01101-4. Epub 2022 Nov 27.

Authors

Sahar A Abdel-Samed¹, Walaa G Hozyen¹, Saeed M Shaaban², Nabil A Hasona¹

Affiliations

¹ Department of Biochemistry, Faculty of Science, Beni-Suef University, Salah Salim St., Beni-Suef, 62511 Egypt.
² Department of Oncology, Faculty of Medicine, Beni-Suef University, Beni Suef, Egypt.

PMID: 38577133
PMCID: PMC10987425 (available on 2025-04-01)
DOI: 10.1007/s12291-022-01101-4

Abstract

Serum microRNAs (miRs) have recently been proposed as potential cancer biomarkers for early detection. Thyroid hormones play a crucial role in human health, and their alterations are linked to a range of diseases, such as breast cancer. The relationship between NF-κβ, TNF-α, and non-coding RNAs is an urgent need for clinical trials. This study aimed to investigate serum expression folds of miR-155 and miR-375 and their correlations with NF-κβ and TNF-α in breast cancer patients. The current study was conducted on 183 unrelated female participants. Serum levels of free T3 and T4, as well as expression folds of miR-155 and miR-375, were significantly higher in patients with fibroadenoma and breast cancer, despite TSH being significantly lower. Additionally, the signaling of TNF-alpha and NF-κβ were found to be significantly upregulated in the serum of patients with breast cancer. Up-regulation of miR-155 and miR-375 expression may be diagnostic biomarkers of breast cancer, pointing to the role of NF-κβ and TNF-α expression in miR-155 and miR-375 expression as therapeutic targets of breast cancer in the future.

Keywords: Breast cancer; NF-κβ; TNF-α; Thyroid profile; miR-155; miR-375; microRNA.

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