Chromatographic Methods for the Analysis of the Antipsychotic Drug Clozapine and Its Major Metabolites: A Review

Hajer Hrichi; Noura Kouki; Nadia Ali Ahmed Elkanzi

doi:10.1093/chromsci/bmae016

Chromatographic Methods for the Analysis of the Antipsychotic Drug Clozapine and Its Major Metabolites: A Review

J Chromatogr Sci. 2024 Apr 4:bmae016. doi: 10.1093/chromsci/bmae016. Online ahead of print.

Authors

Hajer Hrichi¹, Noura Kouki², Nadia Ali Ahmed Elkanzi¹

Affiliations

¹ Chemistry Department, College of Science, Jouf University, P.O. Box: 2014, Sakaka, Saudi Arabia.
² Department of Chemistry, College of Science, Qassim University, Buraidah 51452, Saudi Arabia.

PMID: 38576210
DOI: 10.1093/chromsci/bmae016

Abstract

Clozapine (CLZ), a second-generation antipsychotic, can effectively reduce schizophrenia, bipolar disorder and major depression symptoms. This review provides an overview of all reported chromatographic methods (62 references) for the quantification of CLZ and its two main metabolites, norclozapine and clozapine N-oxide in pharmaceutical formulations, biological matrices and environmental samples.