Novel Variant and Known Mutation in 23S rRNA Gene of Mycoplasma pneumoniae, Northern Vietnam, 2023

Emerg Infect Dis. 2024 May;30(5):1034-1036. doi: 10.3201/eid3005.231632. Epub 2024 Apr 4.

Abstract

During a 2023 outbreak of Mycoplasma pneumoniae-associated community-acquired pneumonia among children in northern Vietnam, we analyzed M. pneumoniae isolated from nasopharyngeal samples. In almost half (6 of 13) of samples tested, we found known A2063G mutations (macrolide resistance) and a novel C2353T variant on the 23S rRNA gene.

Keywords: A2063G; C2353T; Mycoplasma pneumoniae; Vietnam; bacteria; community-acquired pneumonia; macrolide-resistant mutation.

Publication types

  • Research Support, Non-U.S. Gov't
  • Historical Article

MeSH terms

  • Anti-Bacterial Agents / pharmacology
  • Anti-Bacterial Agents / therapeutic use
  • Child
  • Child, Preschool
  • Community-Acquired Infections / epidemiology
  • Community-Acquired Infections / microbiology
  • Drug Resistance, Bacterial / genetics
  • Humans
  • Mutation*
  • Mycoplasma pneumoniae* / classification
  • Mycoplasma pneumoniae* / genetics
  • Pneumonia, Mycoplasma* / epidemiology
  • Pneumonia, Mycoplasma* / history
  • Pneumonia, Mycoplasma* / microbiology
  • RNA, Ribosomal, 23S* / genetics
  • Vietnam / epidemiology

Substances

  • RNA, Ribosomal, 23S
  • Anti-Bacterial Agents