Inflammatory bowel diseases and the clinical course of coronavirus disease 2019 - a Polish single-centre experience from the pre-vaccine era

Estera Banasik; Agnieszka Dobrowolska; Barbara Kołodziejczak; Piotr Eder

doi:10.5114/pg.2023.133479

Inflammatory bowel diseases and the clinical course of coronavirus disease 2019 - a Polish single-centre experience from the pre-vaccine era

Prz Gastroenterol. 2023;18(4):409-415. doi: 10.5114/pg.2023.133479. Epub 2023 Dec 8.

Authors

Estera Banasik¹, Agnieszka Dobrowolska¹, Barbara Kołodziejczak², Piotr Eder¹

Affiliations

¹ Department of Gastroenterology, Dietetics, and Internal Medicine, Poznan University of Medical Sciences, University Clinical Hospital, Poznan, Poland.
² Faculty of Mathematics and Computer Science, Adam Mickiewicz University, Poznan, Poland.

Abstract

Introduction: The data on the relationship between inflammatory bowel diseases (IBD) and the course of COVID-19 from East-Central Europe are scarce.

Aim: To assess the frequency of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection in IBD patients and the impact of IBD on the COVID-19 course from the perspective of a Polish tertiary centre.

Material and methods: Data on SARS-CoV-2 infection were retrospectively collected among IBD patients hospitalized in a Polish tertiary centre from March 2020 to May 2021. A questionnaire was used assessing the IBD characteristics, other comorbidities, and the course of COVID-19.

Results: Among 350 patients, SARS-CoV-2 infection was diagnosed in 32 (9%). Severe COVID-19, defined as the need for hospitalization, was reported in 6 (19%) and mild in 26 (81%) cases. Compared to the mild COVID-19 course, patients with a severe course more often showed a higher IBD activity (3 points [IQR 2.25-3] vs. 1 point [IQR 0-2] in a semi-quantitative scale, p = 0.002), more often received steroids (67% vs. 11%, p = 0.02), and were not treated with biologics (0% vs. 46%, p = 0.07). There was a correlation between the duration of symptomatic infection and the number of comorbidities (r = 0.4, p = 0.04). No death or short-term COVID-19 complications were reported. In 25% of cases, SARS-CoV-2 infection caused new gastrointestinal symptoms.

Conclusions: IBD is not a risk factor for SARS-CoV-2 infection. Steroids and higher IBD clinical activity may increase the risk of severe COVID-19. The prognosis for COVID-19 in our cohort was good. SARS-CoV-2 infection was a common cause of gastrointestinal symptoms.

Keywords: COVID-19; gastrointestinal symptoms; infections; inflammatory bowel diseases; risk factors.