The Correlation between Serum Vitamin D and Total IgE Levels and Chronic Spontaneous Urticaria among Chinese Population: A Retrospective Study

Jia Liu; Fudong Wang; Hui Cao; Yulan Wang; Furong Liang; Shuling Jiang; Haofeng Zhang; Jingying Luo

doi:10.4103/ijd.ijd_634_22

The Correlation between Serum Vitamin D and Total IgE Levels and Chronic Spontaneous Urticaria among Chinese Population: A Retrospective Study

Indian J Dermatol. 2024 Jan-Feb;69(1):106. doi: 10.4103/ijd.ijd_634_22. Epub 2024 Feb 27.

Authors

Jia Liu¹, Fudong Wang¹, Hui Cao¹, Yulan Wang¹, Furong Liang¹, Shuling Jiang¹, Haofeng Zhang², Jingying Luo¹

Affiliations

¹ From the Department of Dermatology, The Second Affiliated Hospital of Guilin Medical University, Guilin City, Guangxi Province, China.
² Department of Otolaryngology, The Second Affiliated Hospital of Guilin Medical University, Guilin City, Guangxi Province, China.

Abstract

Objective: This study aims to investigate the relationship between serum vitamin D, total IgE levels and chronic spontaneous urticaria (CSU).

Methods: We collected data from 101 patients with chronic spontaneous urticaria (experimental group) and 115 healthy normal subjects (control group) in the same period of physical examination.

Results: The results showed that the number of deficient and absolute deficient 25-hydroxyvitamin D in the experimental group was significantly lower than in the control group (P < 0.05). Pearson correlation analysis showed that the activity score of CSU patients was negatively correlated with serum vitamin D (r = -0.2278, P = 0.0220) and positively correlated with IgE (r = 0.2078, P = 0.0380). It was observed that serum vitamin D in CSU patients was negatively correlated with their activity (r = -0.2278, P = 0.0220) and positively correlated with age (r = 0.2675, P = 0.0069). The Point-biserial correlation analysis revealed that gender was positively correlated with serum vitamin D (Pearson correlation coefficient = 0.286, P = 0.004) and UAS score (Pearson correlation coefficient = 0.273, P = 0.006). Ordinal logistic regression analysis showed that only serum vitamin D was correlated to activity scores (P = 0.008). In addition to activity scores, age (P = 0.005) and gender (P = 0.04) were correlated to serum vitamin D.

Conclusion: The activity score of CSU patients was negatively correlated with serum vitamin D and positively correlated with IgE. Serum vitamin D in CSU patients was negatively correlated with activity score and disease duration and positively correlated with age and gender.

Keywords: 25-hydroxyvitamin D; IgE; chronic spontaneous urticaria.