Next Directions in the Neuroscience of Cancers Arising outside the CNS

Moran Amit; Corina Anastasaki; Robert Dantzer; Ihsan Ekin Demir; Benjamin Deneen; Karen O Dixon; Mikala Egeblad; Erin M Gibson; Shawn L Hervey-Jumper; Hubert Hondermarck; Claire Magnon; Michelle Monje; Shorook Na'ara; Yuan Pan; Elizabeth A Repasky; Nicole N Scheff; Erica K Sloan; Sebastien Talbot; Kevin J Tracey; Lloyd C Trotman; Manuel Valiente; Linda Van Aelst; Varun Venkataramani; Humsa S Venkatesh; Paola D Vermeer; Frank Winkler; Richard J Wong; David H Gutmann; Jeremy C Borniger

doi:10.1158/2159-8290.CD-23-1495

Next Directions in the Neuroscience of Cancers Arising outside the CNS

Cancer Discov. 2024 Apr 4;14(4):669-673. doi: 10.1158/2159-8290.CD-23-1495.

Authors

Moran Amit¹, Corina Anastasaki², Robert Dantzer³, Ihsan Ekin Demir⁴, Benjamin Deneen⁵, Karen O Dixon⁶, Mikala Egeblad⁷, Erin M Gibson⁸, Shawn L Hervey-Jumper⁹, Hubert Hondermarck¹⁰, Claire Magnon¹¹, Michelle Monje^{12

13}, Shorook Na'ara¹, Yuan Pan^{3

14}, Elizabeth A Repasky¹⁵, Nicole N Scheff¹⁶, Erica K Sloan¹⁷, Sebastien Talbot¹⁸, Kevin J Tracey¹⁹, Lloyd C Trotman²⁰, Manuel Valiente²¹, Linda Van Aelst²⁰, Varun Venkataramani^{22

23}, Humsa S Venkatesh²⁴, Paola D Vermeer²⁵, Frank Winkler²², Richard J Wong²⁶, David H Gutmann², Jeremy C Borniger²⁰

Affiliations

¹ Department of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, Texas.
² Department of Neurology, Washington University, St. Louis, Missouri.
³ Department of Symptom Research, The University of Texas MD Anderson Cancer Center Houston, Texas.
⁴ Department of Surgery, Klinikum rechts der Isar, Technical University of Munich, Germany; Neural Influences in Cancer (NIC) International Research Consortium, Munich, Germany.
⁵ Center for Cancer Neuroscience and Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, Texas.
⁶ Department of Biomedicine, University of Basel, Basel, Switzerland.
⁷ Departments of Cell Biology and Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland.
⁸ Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Palo Alto, California.
⁹ Department of Neurological Surgery and Weill Neuroscience Institute, University of California, San Francisco, San Francisco, California.
¹⁰ Cancer Neuroscience Laboratory, Hunter Medical Research Institute, School of Biomedical Sciences and Pharmacy, The University of Newcastle, Callaghan NSW 2308, Australia.
¹¹ Laboratory of Cancer and Microenvironment-National Institute of Health and Medical Research (INSERM), Institute of Biology François Jacob-Atomic Energy Commission (CEA), University of Paris Cité, University of Paris-Saclay, Paris, France.
¹² Department of Neurology and Neurological Sciences, Stanford University, Stanford, California.
¹³ Howard Hughes Medical Institute, Stanford, California.
¹⁴ Department of Neuro-Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas.
¹⁵ Department of Immunology, Roswell Park Comprehensive Cancer Center, Buffalo, New York.
¹⁶ Hillman Cancer Center, Department of Neurobiology, University of Pittsburgh, Pittsburgh, Pennsylvania.
¹⁷ Drug Discovery Biology Theme, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville Victoria, Australia.
¹⁸ Department of Biomedical and Molecular Sciences, Queen's University, Kingston, Ontario, Canada.
¹⁹ The Feinstein Institutes for Medical Research, Northwell Health, Manhasset, New York.
²⁰ Cold Spring Harbor Laboratory, Cold Spring Harbor, New York.
²¹ Brain Metastasis Group, Spanish National Cancer Research Centre (CNIO), Madrid, Spain.
²² Neurology Clinic and National Center for Tumor Diseases, University Hospital Heidelberg, Heidelberg, Germany; Clinical Cooperation Unit Neurooncology, German Cancer Research Center, Heidelberg, Germany.
²³ Department of Functional Neuroanatomy, Institute for Anatomy and Cell Biology, Heidelberg University, Heidelberg, Germany.
²⁴ Department of Neurology, Brigham and Women's Hospital, Boston, Massachusetts.
²⁵ Cancer Biology and Immunotherapies Group, Sanford Research, Sioux Falls, South Dakota.
²⁶ Department of Head and Neck Surgery and Oncology, Memorial Sloan Kettering Cancer Center, New York, New York.

PMID: 38571430
DOI: 10.1158/2159-8290.CD-23-1495

Abstract

The field of cancer neuroscience has begun to define the contributions of nerves to cancer initiation and progression; here, we highlight the future directions of basic and translational cancer neuroscience for malignancies arising outside of the central nervous system.

MeSH terms

Central Nervous System
Forecasting
Humans
Neoplasms*
Neurosciences*
Proteomics

Grants and funding

P30 CA045508/CA/NCI NIH HHS/United States