The relationship between paraspinal muscle atrophy and degenerative lumbar spondylolisthesis at the L4/5 level

Paul Köhli; Lukas Schönnagel; Jan Hambrecht; Jiaqi Zhu; Erika Chiapparelli; Ali E Güven; Gisberto Evangelisti; Krizia Amoroso; Roland Duculan; Bernhard Michalski; Jennifer Shue; Koki Tsuchiya; Marco D Burkhard; Andrew A Sama; Federico P Girardi; Frank P Cammisa; Carol A Mancuso; Alexander P Hughes

doi:10.1016/j.spinee.2024.03.016

The relationship between paraspinal muscle atrophy and degenerative lumbar spondylolisthesis at the L4/5 level

Spine J. 2024 Apr 2:S1529-9430(24)00157-8. doi: 10.1016/j.spinee.2024.03.016. Online ahead of print.

Authors

Paul Köhli¹, Lukas Schönnagel², Jan Hambrecht³, Jiaqi Zhu⁴, Erika Chiapparelli⁵, Ali E Güven⁵, Gisberto Evangelisti⁶, Krizia Amoroso⁵, Roland Duculan⁷, Bernhard Michalski⁸, Jennifer Shue⁵, Koki Tsuchiya⁹, Marco D Burkhard⁵, Andrew A Sama⁵, Federico P Girardi⁵, Frank P Cammisa⁵, Carol A Mancuso¹⁰, Alexander P Hughes¹¹

Affiliations

¹ Department of Orthopaedic Surgery, Hospital for Special Surgery, Weill Cornell Medicine, 525 East 71st Street, New York City, NY 10021, USA; Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Center for Musculoskeletal Surgery, Charitéplatz 1, Berlin 10117, Germany; Berlin Institute of Health at Charité - Universitätsmedizin Berlin, BIH Biomedical Innovation Academy, BIH Charité Junior Clinician Scientist Program, Charitéplatz 1, Berlin 10117, Germany.
² Department of Orthopaedic Surgery, Hospital for Special Surgery, Weill Cornell Medicine, 525 East 71st Street, New York City, NY 10021, USA; Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Center for Musculoskeletal Surgery, Charitéplatz 1, Berlin 10117, Germany.
³ Department of Orthopaedic Surgery, Hospital for Special Surgery, Weill Cornell Medicine, 525 East 71st Street, New York City, NY 10021, USA; Department of Trauma Surgery, University Hospital Zurich, Ramistrasse 100, Zurich 8091, Switzerland.
⁴ Department of Epidemiology and Biostatistics, Hospital for Special Surgery, Weill Cornell Medicine, 525 East 71th Street, New York, NY 10021, USA.
⁵ Department of Orthopaedic Surgery, Hospital for Special Surgery, Weill Cornell Medicine, 525 East 71st Street, New York City, NY 10021, USA.
⁶ Department of Orthopaedic Surgery, Hospital for Special Surgery, Weill Cornell Medicine, 525 East 71st Street, New York City, NY 10021, USA; Instituto Ortopedico Rizzoli, Via Giulio Cesare Pupilli 1, Bologna, BO, 40136, Italy.
⁷ Hospital for Special Surgery, New York City, NY, USA.
⁸ Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Center for Musculoskeletal Surgery, Charitéplatz 1, Berlin 10117, Germany.
⁹ Department of Orthopaedic Surgery, Hospital for Special Surgery, Weill Cornell Medicine, 525 East 71st Street, New York City, NY 10021, USA; Department of Orthopaedic Surgery, School of Medicine, Showa University Hospital, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo 142-8666, Japan.
¹⁰ Hospital for Special Surgery, New York City, NY, USA; Weill Cornell Medical College, New York, NY, USA.
¹¹ Department of Orthopaedic Surgery, Hospital for Special Surgery, Weill Cornell Medicine, 525 East 71st Street, New York City, NY 10021, USA. Electronic address: hughesa@hss.edu.

PMID: 38570036
DOI: 10.1016/j.spinee.2024.03.016

Abstract

Background/context: Degenerative lumbar spondylolisthesis (DLS) is a prevalent spinal condition that can result in significant disability. DLS is thought to result from a combination of disc and facet joint degeneration, as well as various biological, biomechanical, and behavioral factors. One hypothesis is the progressive degeneration of segmental stabilizers, notably the paraspinal muscles, contributes to a vicious cycle of increasing slippage.

Purpose: To examine the correlation between paraspinal muscle status on MRI and severity of slippage in patients with symptomatic DLS.

Study design/setting: Retrospective cross-sectional study at an academic tertiary care center.

Patient sample: Patients who underwent surgery for DLS at the L4/5 level between 2016-2018 were included. Those with multilevel DLS or insufficient imaging were excluded.

Outcome measures: The percentage of relative slippage (RS) at the L4/5 level evaluated on standing lateral radiographs. Muscle morphology measurements including functional cross-sectional area (fCSA), body height normalized functional cross-sectional area (HI) of Psoas, erector spinae (ES) and multifidus muscle (MF) and fatty infiltration (FI) of ES and MF were measured on axial MR. Disc degeneration and facet joint arthritis were classified according to Pfirrmann and Weishaupt, respectively.

Methods: Descriptive and comparative statistics, univariable and multivariable linear regression models were utilized to examine the associations between RS and muscle parameters, adjusting for confounders sex, age, BMI, segmental degeneration, and back pain severity and symptom duration.

Results: The study analyzed 138 out of 183 patients screened for eligibility. The median age of all patients was 69.5 years (IQR 62 to 73), average BMI was 29.1 (SD±5.1) and average preoperative ODI was 46.4 (SD±16.3). Patients with Meyerding-Grade 2 (M2, N=25) exhibited higher Pfirrmann scores, lower MF_fCSA and MF_HI, and lower BMI, but significantly more fatty infiltration in the MF and ES muscles compared to those with Meyerding Grade 1 (M1). Univariable linear regression showed that each cm² decrease in MF_fCSA was associated with a 0.9%-point increase in RS (95% CI -1.4 to - 0.4, p<.001), and each cm²/m² decrease in MF_HI was associated with an increase in slippage by 2.2%-points (95% CI -3.7 to -0.7, p=.004). Each 1%-point rise in ES_FI and MF_FI corresponded to 0.17%- (95% CI 0.05-0.3, p=.01) and 0.20%-point (95% CI 0.1-0.3 p<.001) increases in relative slippage, respectively. Notably, after adjusting for confounders, each cm² increase in Psoas_fCSA and cm²/m² in Psoas_HI was associated with an increase in relative slippage by 0.3% (95% CI 0.1-0.6, p=.004) and 1.1%-points (95% CI 0.4-1.7, p=.001). While MF_fCSA tended to be negatively associated with slippage, this did not reach statistical significance (p=.105). However, each 1%-point increase in MF_FI and ES_FI corresponded to increases of 0.15% points (95% CI 0.05-0.24, p=.002) and 0.14% points (95% CI 0.01-0.27, p=.03) in relative slippage, respectively.

Conclusion: This study found a significant association between paraspinal muscle status and severity of slippage in DLS. Whereas higher degeneration of the ES and MF correlate with a higher degree of slippage, the opposite was found for the psoas. These findings suggest that progressive muscular imbalance between posterior and anterior paraspinal muscles could contribute to the progression of slippage in DLS.

Keywords: Degeneration; Degenerative lumbar spondylolisthesis; L4/5 level; Muscle; Paraspinal; Slippage.