Unlocking the power of postbiotics: A revolutionary approach to nutrition for humans and animals

Cell Metab. 2024 Apr 2;36(4):725-744. doi: 10.1016/j.cmet.2024.03.004.

Abstract

Postbiotics, which comprise inanimate microorganisms or their constituents, have recently gained significant attention for their potential health benefits. Extensive research on postbiotics has uncovered many beneficial effects on hosts, including antioxidant activity, immunomodulatory effects, gut microbiota modulation, and enhancement of epithelial barrier function. Although these features resemble those of probiotics, the stability and safety of postbiotics make them an appealing alternative. In this review, we provide a comprehensive summary of the latest research on postbiotics, emphasizing their positive impacts on both human and animal health. As our understanding of the influence of postbiotics on living organisms continues to grow, their application in clinical and nutritional settings, as well as animal husbandry, is expected to expand. Moreover, by substituting postbiotics for antibiotics, we can promote health and productivity while minimizing adverse effects. This alternative approach holds immense potential for improving health outcomes and revolutionizing the food and animal products industries.

Keywords: antioxidant properties; health benefits; immune response; microbial community; postbiotics.

Publication types

  • Review

MeSH terms

  • Animals
  • Anti-Bacterial Agents
  • Gastrointestinal Microbiome*
  • Health Promotion
  • Humans
  • Nutritional Status
  • Probiotics* / pharmacology
  • Probiotics* / therapeutic use

Substances

  • Anti-Bacterial Agents