Assessing the impact of tear direction in coronary artery dissection on thrombosis development: A hemodynamic computational study

Yan Pei; Pan Song; Kaiyue Zhang; Min Dai; Gang He; Jun Wen

doi:10.1016/j.cmpb.2024.108144

Assessing the impact of tear direction in coronary artery dissection on thrombosis development: A hemodynamic computational study

Comput Methods Programs Biomed. 2024 Jun:249:108144. doi: 10.1016/j.cmpb.2024.108144. Epub 2024 Mar 24.

Authors

Yan Pei¹, Pan Song², Kaiyue Zhang¹, Min Dai², Gang He¹, Jun Wen³

Affiliations

¹ Department of Computer Science and Technology, Southwest University of Science and Technology, No. 59, middle of Qinglong Avenue, Fucheng District, Mianyang, 621010, China.
² Department of Cardiology, Mianyang Central Hospital, Mianyang, 621000, China.
³ Department of Computer Science and Technology, Southwest University of Science and Technology, No. 59, middle of Qinglong Avenue, Fucheng District, Mianyang, 621010, China. Electronic address: scu_wenjun@hotmail.com.

PMID: 38569255
DOI: 10.1016/j.cmpb.2024.108144

Abstract

Objective: Iatrogenic coronary artery dissection is a complication of coronary intimal injury and dissection due to improper catheter manipulation. The impact of tear direction on the prognosis of coronary artery dissection (CAD) remains unclear. This study examines the hemodynamic effects of different tear directions (transverse and longitudinal) of CAD and evaluates the risk of thrombosis, rupture and further dilatation of CAD.

Methods: Two types of CAD models (Type I: transverse tear, Type II: longitudinal tear) were reconstructed from the aorto-coronary CTA dataset of 8 healthy cases. Four WSS-based indicators were analyzed, including time-averaged wall shear stress (TAWSS), oscillatory shear index (OSI), relative residence time (RRT), and cross flow index (CFI). A thrombus growth model was also introduced to predict the trend of thrombus growth in CAD with two different tear directions.

Results: For most of the WSS-based indicators, including TAWSS, RRT, and CFI, no statistically significant differences were observed across the CAD models with varying tear directions, except for OSI, where a significant difference was noted (p < 0.05). Meanwhile, in terms of thrombus growth, the thrombus growing at the tear of the Type I (transverse tear) CAD model extended into the true lumen earlier than that of the Type II (longitudinal tear) model.

Conclusions: Numerical simulations suggest that: (1) The CAD with transverse tear have a high risk of further tearing of the dissection at the distal end of the tear. (2) The CAD with longitudinal tear create a hemodynamic environment characterized by low TAWSS and high OSI in the false lumen, which may additionally increase the risk of vessel wall injury. (3) The CAD with transverse tear may have a higher risk of thrombosis and coronary obstruction and myocardial ischemia in the early phase of the dissection.

Keywords: Computational fluid dynamics; Different tear directions; Hemodynamics; Iatrogenic coronary artery dissection; Thrombus growth model.

MeSH terms

Aortic Dissection*
Chronic Disease
Coronary Vessels / diagnostic imaging
Hemodynamics
Humans
Models, Cardiovascular
Stress, Mechanical
Thrombosis* / etiology