On the accuracy of sequence methods for baroreflex sensitivity estimation

Hasana Bagnall-Hare; Violeta I McLoone; John V Ringwood

doi:10.1007/s13246-023-01380-y

On the accuracy of sequence methods for baroreflex sensitivity estimation

Phys Eng Sci Med. 2024 Apr 2. doi: 10.1007/s13246-023-01380-y. Online ahead of print.

Authors

Hasana Bagnall-Hare¹, Violeta I McLoone², John V Ringwood³

Affiliations

¹ Department of Electronic Engineering, Maynooth University, Maynooth, Co. Kildare, Ireland. hasana.bagnallhare.2016@mumail.ie.
² Department of Aero, Mechanical and Electronic Engineering, South East Technological University, Waterford, Co. Carlow, Ireland.
³ Department of Electronic Engineering, Maynooth University, Maynooth, Co. Kildare, Ireland.

PMID: 38564152
DOI: 10.1007/s13246-023-01380-y

Abstract

In the absence of a true gold standard for non-invasive baroreflex sensitivity estimation, it is difficult to quantify the accuracy of the variety of techniques used. A popular family of methods, usually entitled 'sequence methods' involves the extraction of (apparently) correlated sequences from blood pressure and RR-interval data and the subsequent fitting of a regression line to the data. This paper discusses the accuracy of sequence methods from a system identification perspective, using both data generated from a known mathematical model and spontaneous baroreflex data. It is shown that sequence methods can introduce significant bias in the baroreflex sensitivity estimate, even when great care is taken in sequence selection.

Keywords: Baroreflex sensitivity; Sequence methods; System identification.

Grants and funding

WISH Award/National University of Ireland, Maynooth