Photocatalytic redox-neutral α-C(sp3)-H pyridination of glycine derivatives and N-arylamines with cyanopyridines

Changduo Pan; Dongdong Chen; Yangjian Cheng; Jin-Tao Yu

doi:10.1039/d4cc00906a

Photocatalytic redox-neutral α-C(sp³)-H pyridination of glycine derivatives and N-arylamines with cyanopyridines

Chem Commun (Camb). 2024 Apr 18;60(33):4451-4454. doi: 10.1039/d4cc00906a.

Authors

Changduo Pan¹, Dongdong Chen¹, Yangjian Cheng², Jin-Tao Yu²

Affiliations

¹ School of Chemistry and Chemical Engineering, Jiangsu University of Technology, Changzhou 213001, P. R. China. panchangduo@jsut.edu.cn.
² School of Petrochemical Engineering, Changzhou University, Changzhou 213164, P. R. China. yujintao@cczu.edu.cn.

PMID: 38563645
DOI: 10.1039/d4cc00906a

Abstract

A photo-induced α-C(sp³)-H decyanative pyridination of N-arylglycine derivatives with cyanopyridines was developed. This reaction was performed under organic photocatalytic and redox-neutral conditions via a radical-radical cross-coupling process. Besides, the protocol was also suitable for the C(sp³)-H pyridination of N-aryl tetrahydroisoquinolines as well as benzylamines.