Comparison of Enlarged Perivascular Spaces in Early-Onset and Late-Onset Alzheimer Disease-related Cognitive Impairment: A Single Clinic-based Study in South Korea

Na-Yeon Jung; Yuri Je; Hong-Gi Ham; Yu Hyun Park; Tae-Yun Kim; Min-Su Go; Hye-In Lee; Da Eun Kim; Myung Jun Lee; Sang Won Seo; Eun-Joo Kim

doi:10.1097/WAD.0000000000000614

Comparison of Enlarged Perivascular Spaces in Early-Onset and Late-Onset Alzheimer Disease-related Cognitive Impairment: A Single Clinic-based Study in South Korea

Alzheimer Dis Assoc Disord. 2024 Apr 2. doi: 10.1097/WAD.0000000000000614. Online ahead of print.

Authors

Affiliations

¹ Department of Neurology, Pusan National University Yangsan Hospital, Pusan National University School of Medicine, Yangsan.
² Department of Neurology, Pusan National University Hospital, Pusan National University School of Medicine and Biomedical research institute, Busan.
³ Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.

PMID: 38563235
DOI: 10.1097/WAD.0000000000000614

Abstract

We examined whether there were differences in the presence of centrum semiovale-enlarged perivascular spaces (CSO-ePVS) and basal ganglia-ePVS (BG-ePVS) among patients with Alzheimer disease-related cognitive impairment (ADCI) based on their age of onset. Out of a total of 239 patients with cognitive impairment, 155 with positive amyloid-PET results were included. Among these, 43 had early-onset ADCI (EOADCI) and 112 had late-onset ADCI (LOADCI). Patients with LOADCI exhibited a higher prevalence of hypertension, lacunes, white matter hyperintensities, and BG-ePVS than those with EOADCI. BG-ePVS showed a significant correlation with age at the onset and the number of lacunes, whereas CSO-ePVS did not exhibit any association. The higher prevalence of BG-ePVS in patients with LOADCI might be attributable to vascular risk factors (hypertension) and cerebral small vessel disease (CSVD). These findings support the hypothesis that BG-ePVS is associated with CSVD and vascular risk factors, whereas CSO-ePVS is associated with cerebral amyloid angiopathy.