HLA-A*23 Is Associated With Lower Odds of Acute Retroviral Syndrome in Human Immunodeficiency Virus Type 1 Infection: A Multicenter Sub-Saharan African Study

Lovisa Lindquist; William Kilembe; Etienne Karita; Matt A Price; Anatoli Kamali; Pontiano Kaleebu; Jianming Tang; Susan Allen; Eric Hunter; Jill Gilmour; Sarah L Rowland-Jones; Eduard J Sanders; Amin S Hassan; Joakim Esbjörnsson

doi:10.1093/ofid/ofae129

HLA-A*23 Is Associated With Lower Odds of Acute Retroviral Syndrome in Human Immunodeficiency Virus Type 1 Infection: A Multicenter Sub-Saharan African Study

Open Forum Infect Dis. 2024 Mar 13;11(4):ofae129. doi: 10.1093/ofid/ofae129. eCollection 2024 Apr.

Authors

Lovisa Lindquist^{1

2}, William Kilembe³, Etienne Karita³, Matt A Price^{4

5}, Anatoli Kamali⁶, Pontiano Kaleebu^{7

8}, Jianming Tang⁹, Susan Allen^{3

10}, Eric Hunter^{3

10}, Jill Gilmour^{4

11}, Sarah L Rowland-Jones¹², Eduard J Sanders^{12

13}, Amin S Hassan^{1

2

14}, Joakim Esbjörnsson^{1

2

12}

Affiliations

¹ Lund University Centre, Lund University, Lund, Sweden.
² Department of Translational Medicine, Lund University, Lund, Sweden.
³ Rwanda/Zambia HIV Research Group, Kigali, Rwanda and Lusaka, Zambia.
⁴ International AIDS Vaccine Initiative, New York, New York, USA.
⁵ Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, California, USA.
⁶ International AIDS Vaccine Initiative, Nairobi, Kenya.
⁷ Medical Research Council/Uganda Virus Centre Research Institute, Entebbe, Uganda.
⁸ London School of Hygiene and Tropical Medicine, London, United Kingdom.
⁹ Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA.
¹⁰ Emory Vaccine Center, Emory University, Atlanta, Georgia, USA.
¹¹ Human Immunology Laboratory, International AIDS Vaccine Initiative, London, United Kingdom.
¹² Nuffield Department of Clinical Medicine, University of Oxford, Oxford, United Kingdom.
¹³ Aurum Institute, Johannesburg, South Africa.
¹⁴ Kenya Medical Research Institute/Wellcome Trust Research Programme, Kilifi, Kenya.

Abstract

The role of human leukocyte antigen (HLA) class I and killer immunoglobulin-like receptor molecules in mediating acute retroviral syndrome (ARS) during human immunodeficiency virus type 1 (HIV-1) infection is unclear. Among 72 sub-Saharan African adults, HLA-A*23 was associated with lower odds of ARS (adjusted odds ratio, 0.10 [95% confidence interval, .01-.48]; P = .009), which warrants further studies to explore its role on HIV-1-specific immunopathogenesis.

Keywords: Africa; HLA; KIR; acute HIV infection; acute retroviral syndrome.

Abstract

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