Intense prostate-specific membrane antigen receptor expression in coronary artery pypass graft scar tissue: A potential molecular imaging pitfall

Akram Al-Ibraheem; Ahmed Saad Abdlkadir; Nabeela Al-Hajaj; Aysar Khalaf; Samer Salah

doi:10.1177/20584601241240318

Intense prostate-specific membrane antigen receptor expression in coronary artery pypass graft scar tissue: A potential molecular imaging pitfall

Acta Radiol Open. 2024 Mar 28;13(2):20584601241240318. doi: 10.1177/20584601241240318. eCollection 2024 Feb.

Authors

Akram Al-Ibraheem¹, Ahmed Saad Abdlkadir¹, Nabeela Al-Hajaj¹, Aysar Khalaf², Samer Salah³

Affiliations

¹ Department of Nuclear Medicine, King Hussein Cancer Center (KHCC), Amman, Jordan.
² Warith International Cancer Institute, Karbala, Iraq.
³ Department of Medicine, King Hussein Cancer Center (KHCC), Amman, Jordan.

Abstract

⁶⁸Gallium-PSMA positron emission tomography/computer tomography has been utilized recently for the diagnosis and staging of prostate cancer. PSMA is a transmembrane protein that is expressed not only in the prostate gland but also in other tissues. While some pitfalls have been addressed, there are still uncertainties. Herein, we report a 79-year-old male with prostate cancer who underwent a PSMA scan after coronary artery bypass graft surgery, revealing disease progression and PSMA-avid foci at the surgical stitch sites. This report discusses the immunohistochemical and molecular imaging mechanisms underlying PSMA expression in surgical scar tissues, providing critical insights for optimizing radiologic reporting in such situations.

Keywords: 68GA-PSMA; PSMA in CABG; PSMA-avid scar; pitfall; prostate cancer; unaddressed pitfalls.

Publication types

Case Reports