Effect of Prenatal Care on Perinatal Outcomes of Pregnant Women with Diabetes Mellitus: A Systematic Review

Yale J Biol Med. 2024 Mar 29;97(1):49-65. doi: 10.59249/WPTY4075. eCollection 2024 Mar.

Abstract

Objective: to evaluate the effect of prenatal care (PC) on perinatal outcomes of pregnant women with diabetes mellitus (DM). Methods: systematic review developed according to Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) 2020 guidelines and conducted through the population, intervention, control, and outcomes (PICO) strategy. Clinical trials and observational studies were selected, with adult pregnant women, single-fetus pregnancy, diagnosis of DM, or gestational DM and who had received PC and/or nutritional therapy (NT). The search was carried out in PubMed, Scopus, and BIREME databases. The quality of the studies was evaluated using the tools of the National Heart, Lung and Blood Institute-National Institutes of Health (NHLBI-NIH). Results: We identified 5972 records, of which 15 (n=47 420 pregnant women) met the eligibility criteria. The most recurrent outcomes were glycemic control (14 studies; n=9096 participants), hypertensive disorders of pregnancy (2; n=39 282), prematurity (6; n=40 163), large for gestational age newborns (4; n=1556), fetal macrosomia (birth weight >4kg) (6; n=2980) and intensive care unit admission (4; n=2022). Conclusions: The findings suggest that PC interferes with the perinatal outcome, being able to reduce the risks of complications associated with this comorbidity through early intervention, especially when the NT is an integral part of this assistance.

Keywords: diabetes mellitus; nutritional therapy; pregnancy; prenatal care; systematic review.

Publication types

  • Systematic Review
  • Review

MeSH terms

  • Adult
  • Diabetes, Gestational* / diagnosis
  • Diabetes, Gestational* / epidemiology
  • Diabetes, Gestational* / therapy
  • Female
  • Humans
  • Infant, Newborn
  • Pregnancy
  • Pregnant Women
  • Prenatal Care*
  • United States